Results 41 to 50 of about 1,444,306 (236)

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Building a sustainable engineering pipeline: ECSA–academic collaboration on reducing attrition

Cogent Education
The engineering profession is central to South Africa’s innovation, however, persistently high attrition rates within the skills pipeline threaten the sustainability of the engineering workforce.
Nonhle Tracey Sibisi, Lehlohonolo Lefalatsa, Sivuyile Jokazi, Josias Kgwadi Mamabolo, Ada Mukanya Dienga, Brenda Nkhumise   +5 more
doaj   +1 more source

Knowledge management awareness in a research and development facility: Investigating employee perceptions

South African Journal of Information Management, 2013
Background: Research and development (R&D) facilities are dependent on knowledge to develop new and improve existing technologies. R&D employees’ perceptions of the use and management of knowledge are important as these individuals are the source of the ...
Andrea Potgieter, Thami Dube, Chris Rensleigh   +2 more
doaj   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

A Bootstrapping Framework With Interactive Information Modeling for Network Alignment

IEEE Access, 2018
Network alignment is an emerging research topic with great utility value. Its purpose is to recover the hidden alignment between different networks for subsequent cross-network research.
Xuezhi Cao, Weinan Zhang, Yong Yu
doaj   +1 more source

SPI-Hub™: a gateway to scholarly publishing information

Journal of the Medical Library Association, 2020
Background: Advances in the health sciences rely on sharing research and data through publication. As information professionals are often asked to contribute their knowledge to assist clinicians and researchers in selecting journals for publication, the ...
Taneya Y. Koonce, Mallory N. Blasingame, Jerry Zhao, Annette M. Williams, Jing Su, Spencer J. DesAutels, Dario A. Giuse, John D. Clark, Zachary E. Fox, Nunzia Bettinsoli Giuse   +9 more
doaj   +1 more source

Can Triplet Loss Be Used for Multi-Label Few-Shot Classification? A Case Study

Information, 2023
Few-shot learning is a deep learning subfield that is the focus of research nowadays. This paper addresses the research question of whether a triplet-trained Siamese network, initially designed for multi-class classification, can effectively handle multi-
Gergely Márk Csányi, Renátó Vági, Andrea Megyeri, Anna Fülöp , Dániel Nagy, János Pál Vadász, István Üveges   +6 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Knowledge Dichotomy and Semantic Knowledge Management [PDF]

, 2006
Today's business is becoming global and knowledge-intensive. This requires business systems capable of knowledge identification, knowledge acquirement, knowledge distribution and knowledge maintenance in terms of universal knowledge understanding. Semantic knowledge management is expected to meet this requirement.
openaire   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source