Results 61 to 70 of about 6,336,366 (300)
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Peer - Mediated Distributed Knowledge Management [PDF]
, 2003 Distributed Knowledge Management is an approach to knowledge management based on the principle that the multiplicity (and heterogeneity) of perspectives within complex organizations is not be viewed as an obstacle to knowledge exploitation, but rather as
Bonifacio, Matteo +3 more
core +2 more sources
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Risk terrain modeling for monitoring illicit drugs markets across Bogota, Colombia
Crime Science, 2018 Colombia has gone from being a producer and exporter of illicit drugs to becoming a country where consumption also plays an important role. In Bogota, as result of specific policies adopted by the authorities that hit illicit drugs hot spots, the sale ...
José A. Escudero, Boris Ramírez
doaj +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Resilience in the Vaccine Supply Chain: Learning from the COVID-19 Pandemic
VaccinesBackground: The COVID-19 pandemic revealed vaccine supply chain (VSC) weaknesses and enabled post-pandemic analysis highlighting the growing importance of supply chain resilience.
Megan Hay +3 more
doaj +1 more source
Building knowledge-based economies: research projects in knowledge management and knowledge transfer [PDF]
, 2000 Small and medium-sized enterprises (SMEs) are viewed as the growth engines of the new knowledgebased economy. This new economic growth model differs from the old in significant ways, many of which are related to the knowledge base that will be required
Gibson, Virginia R.
core
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Krishikosh: A digital repository to disseminate agricultural knowledge
The Indian Journal of Agricultural Sciences, 2018 Krishikosh is a versatile open access digital repository catering to the needs of Indian National Agricultural Research and Education System (NARES) and has architecture of centralized hosting of content but decentralized management.
RAKHEE SHARMA +7 more
doaj +1 more source
Strategic Knowledge Measurement and Management [PDF]
, 2002 Knowledge and intellectual capital are now recognized as vital resources for organizational survival and competitive advantage. A vast array of knowledge measures has evolved, spanning many disciplines. This chapter reviews knowledge measures focusing on
Boudreau, John W.
core +1 more source