Results 41 to 50 of about 6,391,608 (288)
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Background The COVID-19 pandemic has continued to pose a major global public health risk. The importance of public health surveillance systems to monitor the spread and impact of COVID-19 has been well demonstrated.
Nicholas Papadomanolakis-Pakis +4 more
doaj +1 more source
Glossary of Knowledge Management [PDF]
{Excerpt} Networks of people who work on similar processes or in similar disciplines and who come together to develop and share their knowledge in that field for the benefit of both themselves and their organization. Communities of practice maybe created
Serrat, Olivier
core +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Knowledge Management in Action
The chapter focuses on knowledge management and on knowledge sharing in particular. It is based on a study of a wide range of management consulting firms in Denmark.The purpose of the study has been to gain a more profound understanding of what constitutes knowledge sharing in practice. What does knowledge sharing imply? What are the organizational and
Jacoby Petersen, Nicoline +1 more
openaire +4 more sources
Constant state of change: engagement inequality in temporal dynamic networks
The temporal changes in complex systems of interactions have excited the research community in recent years as they encompass understandings on their dynamics and evolution.
Hadar Miller, Osnat Mokryn
doaj +1 more source
Enriching Knowledge Management Coordination [PDF]
{Excerpt} To manage knowledge—in the sense of making explicit and systematic efforts to enable vital individual and collective knowledge resources to be identified, created, stored, shared, and used for benefit—learning organizations build adaptive and ...
Serrat, Olivier
core +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source

