Results 81 to 90 of about 16,649,211 (297)

A Hybrid Approach: Dynamic Diagnostic Rules for Sensor Systems in Industry 4.0 Generated by Online Hyperparameter Tuned Random Forest

open access: yesSci, 2020
In this work, a hybrid component Fault Detection and Diagnosis (FDD) approach for industrial sensor systems is established and analyzed, to provide a hybrid schema that combines the advantages and eliminates the drawbacks of both model-based and data ...
Ahlam Mallak, Madjid Fathi
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

open access: yesMolecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna   +8 more
wiley   +1 more source

Citations to Iranian English-Language Journals Approved by the Iranian Ministry of Health and Medical Education in Patents Registered in the United States Patent and Trademark Office (USPTO) Database

open access: yesمدیریت اطلاعات سلامت, 2019
Introduction: Assessment of the citations to scientific researches and journals by invention patents is a way to analyze the relationship between the science and technology.
Shirin Zahedi   +2 more
doaj   +1 more source

Attitudes of cancer patients toward ctDNA‐based liquid biopsy for follow‐up

open access: yesMolecular Oncology, EarlyView.
This mixed‐methods study explored cancer patients' experiences, knowledge, and preferences regarding ctDNA‐based liquid biopsy for follow‐up. Awareness of ctDNA was low and recall of previous liquid biopsy was imperfect, yet acceptance was high.
Siddharth Chhajlani   +7 more
wiley   +1 more source

A survey of online social networking used to support health awareness campaigns in the City of Johannesburg metropolitan municipality

open access: yesSouth African Journal of Information Management, 2014
Background: The Department of Health (DoH) at the City of Johannesburg metropolitan municipality in South Africa develops various health awareness campaigns aimed at creating awareness of general health risks within the Johannesburg area.
Karin Eloff, Cornelius J. Niemand
doaj   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

open access: yesFEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell   +8 more
wiley   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

open access: yesFEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss   +7 more
wiley   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

open access: yesFEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty   +13 more
wiley   +1 more source

Comparing five generative AI chatbots’ answers to LLM-generated clinical questions with medical information scientists’ evidence summaries

open access: yesJournal of the Medical Library Association
Objective: To compare answers to clinical questions between five publicly available large language model (LLM) chatbots and information scientists. Methods: LLMs were prompted to provide 45 PICO (patient, intervention, comparison, outcome) questions ...
Mallory N. Blasingame   +6 more
doaj   +1 more source

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