Results 81 to 90 of about 6,336,366 (300)

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

A survey of online social networking used to support health awareness campaigns in the City of Johannesburg metropolitan municipality

South African Journal of Information Management, 2014
Background: The Department of Health (DoH) at the City of Johannesburg metropolitan municipality in South Africa develops various health awareness campaigns aimed at creating awareness of general health risks within the Johannesburg area.
Karin Eloff, Cornelius J. Niemand
doaj   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Enhancing knowledge management in online collaborative learning [PDF]

, 2010
This study aims to explore two crucial aspects of collaborative work and learning: on the one hand, the importance of enabling collaborative learning applications to capture and structure the information generated by group activity and, on the other hand,
Caballé Llobet, Santi, Conesa Caralt, Jordi, Daradoumis Haralabus, Atanasi, Xhafa, Fatos   +3 more
core   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Cluster: Knowledge management [PDF]

The Danish Research Centre for Organic Farming (DARCOF) was established in 1995 as a so-called "centre without walls" where the actual research is performed in interdisciplinary collaboration between the participating research groups.

core  

Knowledge Nodes: the Building Blocks of a Distributed Approach to Knowledge Management [PDF]

, 2002
: In this paper we criticise the objectivistic approach that underlies most current systems for Knowledge Management. We show that such an approach is incompatible with the very nature of what is to be managed (i.e., knowledge), and we argue that this ...
Bonifacio, Matteo, Bouquet, Paolo, Cuel, Roberta   +2 more
core   +7 more sources

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Comparing five generative AI chatbots’ answers to LLM-generated clinical questions with medical information scientists’ evidence summaries

Journal of the Medical Library Association
Objective: To compare answers to clinical questions between five publicly available large language model (LLM) chatbots and information scientists. Methods: LLMs were prompted to provide 45 PICO (patient, intervention, comparison, outcome) questions ...
Mallory N. Blasingame, Taneya Y. Koonce, Annette M. Williams, Jing Su, Dario A. Giuse, Poppy A. Krump, Nunzia B. Giuse   +6 more
doaj   +1 more source

Leveraging management information in improving call centre productivity

South African Journal of Information Management, 2016
Background: The availability and efficient use of management information is one of the key strategic levers in driving growth and competitiveness for companies.
Manthisana Mosese, Martie Mearns
doaj   +1 more source