Results 51 to 60 of about 888,497 (247)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Characteristics of family health professionals in care of violence against children and adolescents

Revista de Enfermagem da Universidade Federal de Santa Maria, 2015
Aim: evaluate the characteristics of family health professionals in the health care of violence cases. Method: this is a cross-sectional study, using data collected through structured interviews of a family health professional census. The outcome was the
Jessye Melgarejo do Amaral Giordani, Pâmela Kurtz Cezar, Gilmara de Campos, Fernanda Giordani Kretzmman, Sheila Kocourek   +4 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Knowledge management in production enterprises

Production Engineering Archives, 2017
The fact that companies are constantly subjected to changes creates challenges connected with constant learning and acquiring knowledge. Companies are forced to act in accordance with the generative strategy.
Bitkowska Agnieszka
doaj   +2 more sources

Using informative priors to account for identifiability issues in occupancy models with identification errors

Peer Community Journal
Non-invasive monitoring techniques like camera traps, autonomous recording units and environmental DNA are increasingly used to collect data for understanding species distribution. These methods have prompted the development of statistical models to suit
Monchy, Célian, Etienne, Marie-Pierre, Gimenez, Olivier   +2 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

VALORAÇÃO DO CONHECIMENTO: SIGNIFICAÇÃO E IDENTIDADE NA AÇÃO ORGANIZACIONAL [PDF]

RAE: Revista de Administração de Empresas, 2013
The valuing of knowledge represents a gap in the field of organizational knowledge. This article aims at answering to which processes are adopted by individuals in the valuing of knowledge in organizations. The research, carried out with HR professionals,
Andrea Cherman, Sandra Regina da Rocha-Pinto   +1 more
doaj  

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source