Results 61 to 70 of about 888,497 (247)
MATEC Web of Conferences, 2016 It has been evidenced that one of the most common causes in the failure of software security is the lack of identification and specification of requirements for information security, it is an activity with an insufficient importance in the software ...
Adán Beltrán G. +5 more
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Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
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Discover Applied SciencesPower grid monitoring alarm event refers to the abnormal state notification triggered by monitoring signals during the operation of various devices, networks or business systems in the power system.
Defa Cao +4 more
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Zhishi guanli luntan, 2017 [Purpose/significance] Enterprise opportunity recognition is one of the key factors affecting enterprise production and innovation. In the process of technology opportunity identification, the fitness between enterprise and technological opportunity ...
Jiang Hong, Zhang Xiaodan, Du Yanjie
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Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Psychology Research and Behavior Management, 2022 Chongrong Huang,1 Liuqi Sun,1 Qingchen Liu,1 Yuzhou Yan,2 Chengyan Li2 1Faculty of Education, Shanghai Normal University, Shanghai, People’s Republic of China; 2College of Philosophy, Law & Political Science, Shanghai Normal University, Shanghai, People ...
Huang C, Sun L, Liu Q, Yan Y, Li C
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The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Challenges of knowledge integration in small and medium enterprises
Knowledge Management & E-Learning: An International Journal, 2014 This study attempts to develop a better understanding of the challenges of knowledge integration (KI) within the innovation process in Small and Medium Enterprises (SMEs).
Kavoos Mohannak
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