Results 61 to 70 of about 1,518,482 (311)

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

FEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia, Anna Dósa, Asha Kiran Maddali, András Jipa, Hajnalka Laczkó‐Dobos, Péter Lőw, Gábor Juhász   +6 more
wiley   +1 more source

Source-To-Sea River Journeys and their Politics of Scale and Knowledge Production: Examining Colorado River Expeditions from the United States through Mexico

Water Alternatives, 2021
In this article we examine an increasingly popular form of water activism – the source-to-sea river journey and its associated narrative – in order to understand its proliferation and implications for water discourse.
Adrianne C. Kroepsch, Caleb Ring, Joanna Clark   +2 more
doaj  

Fūdo in Foreign Language Learning in Japan and Finland

The Copenhagen Journal of Asian Studies, 2023
While the Japanese education system and policy have been studied extensively, Japanese philosophy and thoughts have rarely served as a theoretical and methodological resource in the field of comparative and international education.
Oshie Nishimura-Sahi
doaj   +1 more source

Knowledge-based integrated production management model

, 2010
Purpose - This paper aims to propose a model of production management that integrates knowledge management, as a third dimension, to the production and work dimensions and to identify factors that promote a favorable context for knowledge sharing and ...
Loureiro, Geilson, Edgard Dias Batista, Geilson Loureiro, Batista Junior, Edgard Dias [UNESP], Muniz, Jorge [UNESP], Muniz, Jorge, Jorge Muniz, Batista Junior, Edgard Dias   +7 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Peripheral Contingencies: Experiences of International Scholars in Latvia

Social Inclusion, 2022
This article examines the notion of the academic life course from the perspective of international scholars in Latvia—a research system characterised by “projectarisation,” yet also by aspirations of increased international competitiveness.
Ieva Puzo
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Exploring knowledge production and policy shifts in global higher education

Higher education is undergoing significant transformation in response to global pressures such as policy shifts, internationalization, and changing governance models.
Özkan, Metin, Turan, Selahattin, Kılıç, Duygu Özen   +2 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source