Results 71 to 80 of about 2,788,898 (298)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Labor market decisions after motherhood: The case of Barcelona 1

open access: yesHeliyon
This article analyses mothers' work decisions and their determinants during the first three years of their children's life, based on data from a survey of 1219 mothers in the Barcelona area during 2020.
Cristina de Gispert   +2 more
doaj   +1 more source

Investigating managers in Hungary - What is their knowledge sharing like? [PDF]

open access: yes
Why do people share their knowledge? Who and what inspires them to do it especially within organizations in Hungary and in Central-Eastern Europe? The objective of this paper is to gain an understanding of knowledge sharing. After the introduction of the
Anikó Csepregi, László Áron Kóczy
core  

Pengaruh Information Sharing, Knowledge Sharing Dan Relation Terhadap Performance Perusahaan [PDF]

open access: yes, 2016
In the 21st century is a lot going on to high competition in all fields, especially in the field of global free trade. More than a decade ago, the leaders of ASEAN countries (Indonesia, Malaysia, Philippines, Singapore, Thailand, Brunei Darussalam ...
Mandasari, N. (Nirmala)   +1 more
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

Pengaruh Knowledge Sharing Terhadap Individual Innovation Capability Dan Kinerja Karyawan (Studi Pada PT. Pln (Persero) Unit Induk Pembangunan Sulawesi Bagian Utara) [PDF]

open access: yes, 2017
Jenis penelitian ini adalah asosiatif yang bertujuan untuk mengetahui Pengaruh Struktur Modal Dan Profitabilitas Terhadap Nilai Perusahaan Dengan Insider Ownership Sebagai Variabel Intervening Pada Perusahaan Pertambangan Yang Terdaftar di BEI Periode ...
Aristanto, D. B. (Deny)
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Innovation Factory for Sharing Knowledge

open access: yesSymphonya, 2015
The introduction of an innovative organization like Digital Borgo in a strongly conservative context, made mostly by SMEs and few big companies, often with no relationships to each other modify their interests in collaborating and exchanging knowledge ...
Chiara Patitucci, Andrea Risa
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

open access: yesFEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand   +2 more
wiley   +1 more source

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