Results 71 to 80 of about 536,466 (264)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Innovation Factory for Sharing Knowledge
Symphonya, 2015 The introduction of an innovative organization like Digital Borgo in a strongly conservative context, made mostly by SMEs and few big companies, often with no relationships to each other modify their interests in collaborating and exchanging knowledge ...
Chiara Patitucci, Andrea Risa
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Sharing the Knowledge: Communication and Dissemination
Abstract All the great potential of home cage monitoring (HCM) will remain unrealised if the knowledge about its value is not communicated and disseminated efficiently via appropriate channels to the relevant target audiences.
Čater, Maša, Hölter, Sabine M.
openaire +2 more sources
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Relationship between Employees' Perceptions of Knowledge Sharing Culture and Organizational Factors [PDF]
مدیریت بهره وری, 2009 Nowadays knowledge sharingas an element of knowledge management process has a key role in the development of public sector organizations. This article deals with measuring the perception of knowledge sharing culture in the public sector organizations ...
FarajAllah Rahnavard, Fatemeh Sadr
doaj
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Sharing knowledge under pressure
i-comCrises are a moment of high information scarcity contrasted by an immense information need. This study examines the potential of scientists as sense-giving actors on social media, exploring the ethical and strategic challenges they face.
Jung Anna-Katharina +2 more
doaj +1 more source
Wikimedia and Knowledge-Sharing
, 2019 Presentation given to NetIKX - The Network for Information and Knowledge Exchange, in London on 24 January 2019.
openaire +1 more source