Results 81 to 90 of about 536,466 (264)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Sharing assessed knowledge, sharing heritage

open access: yesArcheologia e Calcolatori
Within the CHANGES Project, Spoke 8 focuses on integrated advanced technologies and scientific methods to enhance the sustainability and resilience of Tangible Cultural Heritage (TCH). The project fosters the creation of a transdisciplinary unit aimed at improving the knowledge, understanding, management, and dissemination of TCH contexts and assets ...
P. Carafa, N. Cecconi, F. De Stefano
openaire   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

open access: yesMolecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant   +7 more
wiley   +1 more source

Teachers’ Awareness of Knowledge Management and Knowledge Sharing behaviour in Secondary Schools-Nigeria

open access: yesInternational Journal of Information Science and Management, 2020
The study investigated teachers’ awareness of knowledge management and knowledge sharing behaviour in secondary schools-Nigeria. Three objectives/ purposes guided the study and the hypothesis was tested at significance level of 0.05.
Ogagaoghene Uzezi Idhalama   +1 more
doaj  

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

Developing a knowledge sharing strategy for a South African IT consultancy

open access: yesSouth African Journal of Information Management
Background: Information technology (IT) consultants find themselves in a fast-paced, fast-changing environment where client satisfaction, project success and problem-solving are their greatest responsibilities.
Daniëlle Swanepoel   +2 more
doaj   +1 more source

KNOWLEDGE SHARING BERBASIS KARAKTER PEMUSTAKA

open access: yesJurnal Pustaka Ilmiah, 2019
This research discusses about knowledge sharing based on user’s character. The objectives are to measure part of user’s character indicators that supporting knowledge sharing as: honesty, opennes, and responsibel.
Tri Hardiningtyas
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

open access: yesFEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer   +7 more
wiley   +1 more source

Akuisisi dan Budaya Knowledge Sharing

open access: yesComTech, 2011
Large companies which are experiencing barriers in innovation often take a radical step to acquire knowledge, namely acquisition. Though innovation is not the only reason, acquisition will result in the company wishes to achieve competitive advantage ...
Nuril Kusumawardhani Soeprapto Putri
doaj   +1 more source

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