Results 61 to 70 of about 1,241,263 (261)

La Gestion des Connaissances en Innovation Ouverte : une Revue de Littérature

open access: yesJournal of Information Sciences
Cet article fournit une analyse détaillée de l'intersection entre la gestion des connaissances (KM) et l'innovation ouverte. Il explore comment l'intégration et le partage des connaissances à la fois internes et externes à une organisation sont cruciaux
Wiame BAKKALI, Noureddine ELMQADDEM
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Citizen Participation in Digitised Environments in Berlin: Visualising Spatial Knowledge in Urban Planning

open access: yesUrban Planning, 2020
Digital information and communication technologies influence not only on urban planning but also citizen participation. The increasing level of politically driven involvement of the public in urban planning processes has led to the development of new ...
Ajit Singh, Gabriela Christmann
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

Postmodernity and Deviations

open access: yesПроблеми на постмодерността, 2012
The article analyzes the process which makes deviant behavior possible and the process in which deviance is, from a certain point, perceived as the norm.
Lyuba Spasova
doaj  

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

Knowledge Society

open access: yesRevista Tecnológica-Educativa Docentes 2.0 (RTED), 2019
La noción de sociedad del conocimiento es una innovación de las tecnologías de la información y las comunicaciones, donde el incremento en las transferencias de la información modificó en muchos sentidos la forma en que desarrollan muchas actividades en la sociedad moderna. Fue utilizada por primera vez por el filósofo de la gestión empresarial Drucker,
openaire   +3 more sources

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

open access: yesFEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara   +3 more
wiley   +1 more source

Aligning European OA policies with the Horizon 2020 OA policy

open access: yesInsights: The UKSG Journal, 2015
This article considers that the Horizon 2020 (H2020) Open Access (OA) policy can be adopted as a policy model in European Research Area (ERA) countries for the development and increasing alignment of OA policies.
Mafalda Picarra   +4 more
doaj   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

open access: yesFEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell   +8 more
wiley   +1 more source

Home - About - Disclaimer - Privacy