Results 101 to 110 of about 4,007,505 (289)

Knowledge Administration Within Modern Business Structures [PDF]

open access: yesOvidius University Annals: Economic Sciences Series
The research aims to develop a conceptual framework for analyzing the relationship of determination between the dimensions of the organization that characterize the elements of intellectual capital and each of the stages of the organization, taking ...
Anca Madalina Bogdan   +2 more
doaj  

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

open access: yesFEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth   +6 more
wiley   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

open access: yesFEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Frost-salt Testing Non-air Entrained High-Performance Fly-ash Concrete. Part I: Relations Liquid uptake - Internal Cracking – Scaling

open access: yesNordic Concrete Research
The surface scaling of low CO2-emission High Performance Concretes (HPC) was studied in freeze/thaw performance tests with a 3 mm layer of 3% NaCl on the surface to investigate whether such concretes can be made frost durable without air entrainment ...
Asadi Iman   +3 more
doaj   +1 more source

Justification in Context [PDF]

open access: yes, 2003
Determining knowledge happens by indexically attuned\ud justification. One may also say that knowledge comes\ud without justification if standards for knowledge are\ud measured by fancy requirements. A lower setting of scores\ud brings justification back.
Potrč, Matjas
core  

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

open access: yesFEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik   +6 more
wiley   +1 more source

Knowledge Base Structure [PDF]

open access: yes, 2006
In a unified conceptual model for first-order knowledge bases the data and knowledge are modelled formally in a uniform way. A knowledge base is maintained by modifying its conceptual model and by using those modifications to specify changes to its implementation.
openaire   +1 more source

Peer - Mediated Distributed Knowledge Management [PDF]

open access: yes, 2003
Distributed Knowledge Management is an approach to knowledge management based on the principle that the multiplicity (and heterogeneity) of perspectives within complex organizations is not be viewed as an obstacle to knowledge exploitation, but rather as
Bonifacio, Matteo   +3 more
core   +2 more sources

Intercompartmental communication in senescence

open access: yesFEBS Open Bio, EarlyView.
Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz   +3 more
wiley   +1 more source

Knowledge-Based Discrete Optimalization of Truss Structures

open access: yesEngineering Transactions, 1995
The knowledge-based approach to discrete optimization is presented in the paper. The minimization problem characterized by linear objective function and arbitrary constraints is considered when design variables have to be chosen from a set of discrete ...
M. Pyrz
doaj  

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