Results 51 to 60 of about 913,222 (259)

Exogenous and endogenous knowledge structures in dual-mode course deliveries

Computers and Education Open, 2020
Learning Management Systems (LMS) have facilitated any-time any-place learning; thereby enabling educational institutions to embrace dual-mode teaching by engaging with on- and off-campus student cohorts.
Sanjay Mathrani, Anuradha Mathrani, Madhury Khatun   +2 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gabor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source

Analysis of Concrete Air Voids: Comparing OpenAI-Generated Python Code with MATLAB Scripts and Enhancing 2D Image Processing Using 3D CT Scan Data

Buildings
The air void system in concrete significantly affects its mechanical, thermal, and frost durability properties. This study explored the use of ChatGPT, an AI tool, to generate Python code for analyzing air void parameters in hardened concrete, such as ...
Iman Asadi, Andrei Shpak, Stefan Jacobsen   +2 more
doaj   +1 more source

A Knowledge Structures Perspective on the Scholarship of Teaching & Learning

International Journal for the Scholarship of Teaching and Learning, 2009
The application of concept mapping to university teaching has revealed the significance of knowledge structures in the process of student learning. The method highlights the negative influence of linearity in promoting an environment where non-learning ...
Ian Kinchin
doaj   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

台灣原住民族知識組織架構建構方法之探討 A Study on the Method of Constructing Taiwan Aboriginal Knowledge Organization Structure [PDF]

Jiàoyù zīliào yǔ túshūguǎn xué, 2010
近年來,原住民族知識組織架構愈來愈受各界的關注與重視,然而由於過去原住民知識大多皆以口傳為主,顯少有文字記載,故原住民族知識組織架構建構之不完整性是可想而知的。 為因應此劃時代之趨勢與需求,本研究旨在提出一套建構「台灣原住民族知識組織架構」之方法與步驟:透過對各種「知識組織系統」類型特色與呈現方式的分析,本研究認為「分類架構」應是目前較適用於呈現原住民族領域知識的知識組織系統;再藉由「領域分析」方法的探討,整合出台灣原住民族領域知識分析之整體流程;並根據現有之原住民族知識組織架構及其建構之相關研究 ...
Hsueh-Hua Chen
doaj