Results 111 to 120 of about 2,109,221 (325)

Global environmental knowledge synthesis: What’s in it for national action?

Sustainability: Science, Practice, & Policy
Global environmental assessments (GEAs) support international environmental governance by synthesizing state-of-the-art scientific knowledge. Increasingly, they also articulate solutions to environmental risks.
Salla Rantala, Jason Jabbour, Juuli Närhi   +2 more
doaj   +1 more source

Identifying prognostic targets in metastatic prostate cancer beyond AR

FEBS Open Bio, EarlyView.
Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng, Eric Feng, Tracy Berg, Isabella S. Nguyen, Lilac G. Nguyen, William Chen, Meng Zhang, David Quigley, Marina Sharifi, Haolong Li, Ilsa Coleman, Peter S. Nelson, Martin Sjöström, Shuang G. Zhao   +13 more
wiley   +1 more source

A question of trust: can we build an evidence base to gain trust in systematic review automation technologies?

Systematic Reviews, 2019
Background Although many aspects of systematic reviews use computational tools, systematic reviewers have been reluctant to adopt machine learning tools. Discussion We discuss that the potential reason for the slow adoption of machine learning tools into
Annette M. O’Connor, Guy Tsafnat, James Thomas, Paul Glasziou, Stephen B. Gilbert, Brian Hutton   +5 more
doaj   +1 more source

The synthesis of knowledge engineering and software engineering [PDF]

, 1992
Mildred L. G. Shaw, Brian R. Gaines
openalex   +1 more source

Earthing effects on mitochondrial function: ATP production and ROS generation

FEBS Open Bio, EarlyView.
In contrast to sham and naive controls, grounded mitochondria not only exhibit significantly enhanced energy production but also demonstrate a remarkable reduction in membrane potential and oxidative stress. This suggests a profound improvement in mitochondrial health, presenting a promising avenue for therapeutic interventions.
Cecilia Giulivi, Richard Kotz
wiley   +1 more source

A rapid research needs appraisal methodology to identify evidence gaps to inform clinical research priorities in response to outbreaks—results from the Lassa fever pilot

BMC Medicine, 2019
Background Infectious disease epidemics are a constant threat, and while we can strengthen preparedness in advance, inevitably, we will sometimes be caught unaware by novel outbreaks.
Louise Sigfrid, Catrin Moore, Alex P. Salam, Nicola Maayan, Candyce Hamel, Chantelle Garritty, Vittoria Lutje, Brian Buckley, Karla Soares-Weiser, Rachel Marshall, Mike Clarke, Peter Horby   +11 more
doaj   +1 more source

Knowledge synthesis and the Canadian Institutes of Health Research [PDF]

Systematic Reviews, 2012
The Canadian Institutes of Health Research (CIHR) is Canada's premier health-research funding agency. We fund nearly 14,000 researchers and trainees in four theme areas: biomedical, clinical, health services, and population and public-health research.
openaire   +4 more sources

Serotonergic and Dopaminergic Function in Neuropsychiatrically Asymptomatic People With HIV on Antiretroviral Therapy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective People with HIV (PWH) on antiretroviral therapy (ART) still experience neurocognitive dysfunction and accelerated brain volume loss. To assess whether the serotonergic and dopaminergic systems are affected, we used [11C]DASB positron emission tomography (PET) to assess presynaptic serotonergic function and [18F]FDOPA PET to measure ...
Chuen‐Yen Lau, Anna Lyndaker, Swati Shah, Paul Wakim, Amelia Mitchell, Cynthia Monroe, Alan Kim, Tracy L. Cropper, Govind Nair, Joseph Snow, Bryan R. Smith, Avindra Nath, Dima A. Hammoud   +12 more
wiley   +1 more source

Synthesis of application specific processor architectures for ultra-low energy consumption

, 2014
In this paper we suggest that further energy savings can be achieved by a new approach to synthesis of embedded processor cores, where the architecture is tailored to the algorithms that the core executes.
Kazmierski, T J, Leech, Charles
core  

Knowledge compilation = query rewriting + view synthesis [PDF]

, 2002
Marco Cadoli, Toni Mancini
openalex   +1 more source