Results 51 to 60 of about 3,241,412 (295)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Cross-sectional study characterizing the porcine faecal microbiome in commercial farms

Porcine Health Management
Background The gut microbiome is regarded as an important source of information to better understand and improve health and growth in animals. However, there is a knowledge gap concerning the effects of management and health in commercial farms on the ...
Mario Andre S. Ornelas, Juan M. Ortiz Sanjuán, Finola C. Leonard, Carla Correia-Gomes, Jordi Estellé, Lorcan O’Neill, Edgar Garcia Manzanilla   +6 more
doaj   +1 more source

Rebuilding Trust in Broken Systems? Populist Party Success and Citizens’ Trust in Democratic Institutions

Politics and Governance, 2020
What effect does the recent rise of populist parties harnessing an anti-system rhetoric have on political trust? Will citizens become disenchanted with and lose trust in the political system, or could populist party success even stimulate a growth of ...
Marlene Mauk
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Bookseller’s Classification: Classification Examples and Criteria of Croatian Booksellers in Sales Catalogs and Book Lists from the Beginning of the 20th Century

Libellarium: Journal for the Research of Writing, Books, and Cultural Heritage Institutions, 2012
The aim of the paper is to conduct research on the topic of ways of bookstore (sales) classification of Croatian bookstores from the beginning of the 20th century.
Nada Topić
doaj   +1 more source

Knowledge transfer and its contexts [PDF]

Studies in History and Philosophy of Science Part A, 2019
Knowledge transfer across different contexts has become an increasingly prevalent feature of current science. As such, it is a relevant topic also for historians and philosophers of science. This special issue presents a set of papers that study knowledge transfer in various disciplines.
Herfeld, Catherine, Lisciandra, Chiara
openaire   +3 more sources

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

New content, design, and marketing trends in commercial publishing

Libellarium: Journal for the Research of Writing, Books, and Cultural Heritage Institutions, 2009
The aim of the paper is to analyse the actual status of book publishing in Croatia, envisage the trends of its future development and, by analyzing the current state of affairs and new book marketing trends, draw conclusions as to which directions the ...
Leonardo Blažević
doaj   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

The profile of a professional reader: Ivo Vojnović’s reading practices

Libellarium: Journal for the Research of Writing, Books, and Cultural Heritage Institutions, 2012
The aim of the paper is to reconstruct the reading profile of Ivo Vojnović using the literature overview and the analysis of his personal correspondence, in order to answer the research questions suggested in Robert Darnton’s methodological texts.
Nada Topić
doaj   +1 more source