Results 31 to 40 of about 449,358 (242)

Comparative effectiveness and safety of pharmacological and non-pharmacological interventions for insomnia: an overview of reviews

Systematic Reviews, 2019
Background This review aimed to assess the existing evidence regarding the clinical effectiveness and safety of pharmacological and non-pharmacological interventions in adults with insomnia and identify where research or policy development is needed ...
Patricia Rios, Roberta Cardoso, Deanna Morra, Vera Nincic, Zahra Goodarzi, Bechara Farah, Sharada Harricharan, Charles M. Morin, Judith Leech, Sharon E. Straus, Andrea C. Tricco   +10 more
doaj   +1 more source

Comparative efficacy and complications of long-acting and intermediate-acting insulin regimens for adults with type 1 diabetes: an individual patient data network meta-analysis

BMJ Open, 2022
Objective To examine the comparative efficacy and complications of long-acting and intermediate-acting insulin for different patient characteristics for type 1 diabetes mellitus (T1DM).Design Systematic review and individual patient data (IPD) network ...
Dimitris Mavridis, Sharon E Straus, Lorenzo Moja, Mike Clarke, Andrea C Tricco, Lesley Stewart, Areti Angeliki Veroniki, Catrin Tudur-Smith, Catherine H Yu, Georgios Seitidis   +9 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Characterizing Canadian funded partnered health research projects between 2011 and 2019: a retrospective analysis

Health Research Policy and Systems, 2023
Background and Aims Involving research users in collaborative research approaches may increase the relevance and utility of research findings. Our primary objectives were to (i) identify and describe characteristics of Canadian federally and provincially
Kathryn M. Sibley, Masood Khan, Alexie J. Touchette, Leah K. Crockett, S. Michelle Driedger, Heather L. Gainforth, Devashree Prabhu, Dawn Steliga, Olivia Tefft, Ian D. Graham   +9 more
doaj   +1 more source

Safety and effectiveness of dose-sparing strategies for intramuscular seasonal influenza vaccine: a rapid scoping review

BMJ Open, 2021
Background The objective of this rapid scoping review was to identify studies of dose-sparing strategies for administration of intramuscular seasonal influenza vaccines in healthy individuals of all ages.Methods Comprehensive literature searches were ...
Sharon E Straus, Jesmin Antony, Andrea C Tricco, Carole Lunny, Patricia Rios, Chantal Williams, Naveeta Ramkissoon   +6 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Canadian Chronic Kidney Disease Clinics: A National Survey of Structure, Function and Models of Care

Canadian Journal of Kidney Health and Disease, 2014
Background: The goals of care for patients with chronic kidney disease (CKD) are to delay progression to end stage renal disease, reduce complications, and to ensure timely transition to dialysis or transplantation, while optimizing independence.
Adeera Levin, Soroka Steven, Allu Selina, Au Flora, Gil Sarah, Manns Braden   +5 more
doaj   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Use of implementation science methods to design Wellness Hub, a responsive program to address long-term care and retirement homes’ challenges during the COVID-19 pandemic

BMC Health Services Research
Background Long-term care and retirement homes (LTCH/RH) faced systemic challenges that were exacerbated by the COVID-19 pandemic. Homes faced three major challenges over the course of the pandemic: implementing infection prevention and control (IPAC ...
Christine Fahim, Keelia Quinn de Launay, Vanessa Bach, Jessica Firman, Claire R. Gapare, Vincenza Gruppuso, Ayaat T. Hassan, Ana Mrazovac, Temi Odunuga, Nimitha Paul, Lisa Strifler, Alyson Takaoka, Elikem Togo, Hui Juan Chelsea Gao, Jamie M. Boyd, Sharon E. Straus   +15 more
doaj   +1 more source

Guidance for using artificial intelligence for title and abstract screening while conducting knowledge syntheses

BMC Medical Research Methodology, 2021
Background Systematic reviews are the cornerstone of evidence-based medicine. However, systematic reviews are time consuming and there is growing demand to produce evidence more quickly, while maintaining robust methods.
Candyce Hamel, Mona Hersi, Shannon E. Kelly, Andrea C. Tricco, Sharon Straus, George Wells, Ba’ Pham, Brian Hutton   +7 more
doaj   +1 more source