Results 41 to 50 of about 397,968 (266)

Efficacy and safety of tocilizumab in Korean patients with active rheumatoid arthritis [PDF]

The Korean Journal of Internal Medicine, 2019
Background/Aims To investigate the efficacy and safety of tocilizumab (TCZ) humanized anti-interleukin-6 receptor monoclonal antibody, in Korean patients with active rheumatoid arthritis (RA) refractory to conventional disease modifying anti-rheumatic ...
Han Joo Baek, Mie Jin Lim, Won Park, Sung Hwan Park, Seung-Cheol Shim, Dae-Hyun Yoo, Hyun Ah Kim, Soo Kon Lee, Yun Jong Lee, Young Eun Park, Hoon-Suk Cha, Yeong-Wook Song   +11 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Analysis of the relationship between sugar intake and cancer prevalence: a cross-sectional study using the 8th Korea National Health and Nutrition Examination Survey [PDF]

Korean Journal of Community Nutrition
Objectives This study aimed to analyze the association between sugar intake and cancer risk among Korean adults aged 19 years and older. Methods A total of 13,016 adults aged 19 years and older who participated in the 8th Korea National Health and ...
Hye-Ryun Kim, Soo-Kyung Lee
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Contemporary cultures and their relationship to adolescent behavior (Korean culture) as a model

مجلة فنون البصرة, 2023
Going into any aspect of adolescence is one of the important basics for evaluating society, this is due to the importance of this age stage that determines building the personality of a normal individual and establishing him in a positive way for his ...
Zahra Hadi Kazem
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Simple and effective neural coreference resolution for Korean language

ETRI Journal, 2021
We propose an end‐to‐end neural coreference resolution for the Korean language that uses an attention mechanism to point to the same entity. Because Korean is a head‐final language, we focused on a method that uses a pointer network based on the head ...
Cheoneum Park, Joonho Lim, Jihee Ryu, Hyunki Kim, Changki Lee   +4 more
doaj   +1 more source

Neck Circumference as a Predictor of Insulin Resistance in People with Non-alcoholic Fatty Liver Disease

Journal of Obesity & Metabolic Syndrome, 2023
Background : Insulin resistance is common in individuals with non-alcoholic fatty liver disease (NAFLD). Because insulin resistance is a predictive factor for advanced liver diseases in people with NAFLD, efforts have been made to predict it through ...
Da-Hye Son, Jee Hye Han, Jun-Hyuk Lee
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Association between serum 25-hydroxyvitamin D levels and myopia in general Korean adults

Indian Journal of Ophthalmology, 2020
Purpose: We performed this study to determine the association between serum 25-hydroxyvitamin D [25(OH) D] level and myopia in adults. Methods: A total of 25,199 subjects aged ≥20 years were included from the National Health and Nutrition Examination ...
Byung J Jung, Donghyun Jee
doaj   +1 more source