Results 21 to 30 of about 337 (154)

Evaluasi Sistem Informasi Menggunakan Technology Acceptance Model dengan Penambahan Variabel Eksternal

Jurnal Teknologi Informasi dan Ilmu Komputer, 2020
Dalam rangka pengelolaan akademik, sebelum mengikuti perkuliahan mahasiswa wajib untuk mengisi KRS. KRS (Kartu Rencana Studi) berfungsi untuk mengelola mata kuliah yang akan diambil pada Semester yang bersangkutan oleh mahasiswa, pengisian KRS dilakukan ...
Ria Andriani, Arief Setyanto, Asro Nasiri   +2 more
doaj   +1 more source

Allosteric Modulation of GABAA Receptors by an Anilino Enaminone in an Olfactory Center of the Mouse Brain

Pharmaceuticals, 2014
In an ongoing effort to identify novel drugs that can be used as neurotherapeutic compounds, we have focused on anilino enaminones as potential anticonvulsant agents.
Thomas Heinbockel, Ze-Jun Wang, Patrice L. Jackson-Ayotunde   +2 more
doaj   +1 more source

Monitoring of B Cell in Kidney Transplantation: Development of a Novel Clusters Analysis and Role of Transitional B Cells in Transplant Outcome

Diagnostics, 2021
Background: B lymphocytes (BL) seem to play an important role in transplantation, although the and role of different subpopulations in monitoring and outcome is not clear.
Rafael Alfaro, Isabel Legaz, Gema González-Martínez, Víctor Jimenez-Coll, Helios Martínez-Banaclocha, José Antonio Galián, Carmen Botella, Jesús de la Peña-Moral, María Rosa Moya-Quiles, José Antonio Campillo, Alfredo Minguela, Santiago Llorente, Manuel Muro   +12 more
doaj   +1 more source

Evaluation of Non-Laboratory and Laboratory Prediction Models for Current and Future Diabetes Mellitus: A Cross-Sectional and Retrospective Cohort Study.

PLoS ONE, 2016
BackgroundVarious diabetes risk scores composed of non-laboratory parameters have been developed, but only a few studies performed cross-validation of these scores and a comparison with laboratory parameters. We evaluated the performance of diabetes risk
Chang Ho Ahn, Ji Won Yoon, Seokyung Hahn, Min Kyong Moon, Kyong Soo Park, Young Min Cho   +5 more
doaj   +1 more source

Comparative genomic characterization of three Streptococcus parauberis strains in fish pathogen, as assessed by wide-genome analyses.

PLoS ONE, 2013
Streptococcus parauberis, which is the main causative agent of streptococcosis among olive flounder (Paralichthys olivaceus) in northeast Asia, can be distinctly divided into two groups (type I and type II) by an agglutination test.
Seong-Won Nho, Jun-ichi Hikima, Seong Bin Park, Ho Bin Jang, In Seok Cha, Motoshige Yasuike, Yoji Nakamura, Atsushi Fujiwara, Motohiko Sano, Kinya Kanai, Hidehiro Kondo, Ikuo Hirono, Haruko Takeyama, Takashi Aoki, Tae-Sung Jung   +14 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Comparison of three clinical scoring tools for bronchiolitis to predict the need for respiratory support and length of stay in neonates and infants up to three months of age

Frontiers in Pediatrics, 2023
BackgroundBronchiolitis severity can be assessed using different clinical scores. Some of the most used are the Wang Bronchiolitis Severity Score (WBSS), the Kristjansson Respiratory Score (KRS), and the Global Respiratory Severity Score (GRSS ...
Domenico Umberto De Rose, Chiara Maddaloni, Ludovica Martini, Annabella Braguglia, Andrea Dotta, Cinzia Auriti   +5 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source