Results 21 to 30 of about 340 (151)

Allosteric Modulation of GABAA Receptors by an Anilino Enaminone in an Olfactory Center of the Mouse Brain

Pharmaceuticals, 2014
In an ongoing effort to identify novel drugs that can be used as neurotherapeutic compounds, we have focused on anilino enaminones as potential anticonvulsant agents.
Thomas Heinbockel, Ze-Jun Wang, Patrice L. Jackson-Ayotunde   +2 more
doaj   +1 more source

Comparative genomic characterization of three Streptococcus parauberis strains in fish pathogen, as assessed by wide-genome analyses.

PLoS ONE, 2013
Streptococcus parauberis, which is the main causative agent of streptococcosis among olive flounder (Paralichthys olivaceus) in northeast Asia, can be distinctly divided into two groups (type I and type II) by an agglutination test.
Seong-Won Nho, Jun-ichi Hikima, Seong Bin Park, Ho Bin Jang, In Seok Cha, Motoshige Yasuike, Yoji Nakamura, Atsushi Fujiwara, Motohiko Sano, Kinya Kanai, Hidehiro Kondo, Ikuo Hirono, Haruko Takeyama, Takashi Aoki, Tae-Sung Jung   +14 more
doaj   +1 more source

Evaluasi Sistem Informasi Menggunakan Technology Acceptance Model dengan Penambahan Variabel Eksternal

Jurnal Teknologi Informasi dan Ilmu Komputer, 2020
Dalam rangka pengelolaan akademik, sebelum mengikuti perkuliahan mahasiswa wajib untuk mengisi KRS. KRS (Kartu Rencana Studi) berfungsi untuk mengelola mata kuliah yang akan diambil pada Semester yang bersangkutan oleh mahasiswa, pengisian KRS dilakukan ...
Ria Andriani, Arief Setyanto, Asro Nasiri   +2 more
doaj   +1 more source

Evaluation of Non-Laboratory and Laboratory Prediction Models for Current and Future Diabetes Mellitus: A Cross-Sectional and Retrospective Cohort Study.

PLoS ONE, 2016
BackgroundVarious diabetes risk scores composed of non-laboratory parameters have been developed, but only a few studies performed cross-validation of these scores and a comparison with laboratory parameters. We evaluated the performance of diabetes risk
Chang Ho Ahn, Ji Won Yoon, Seokyung Hahn, Min Kyong Moon, Kyong Soo Park, Young Min Cho   +5 more
doaj   +1 more source

Monitoring of B Cell in Kidney Transplantation: Development of a Novel Clusters Analysis and Role of Transitional B Cells in Transplant Outcome

Diagnostics, 2021
Background: B lymphocytes (BL) seem to play an important role in transplantation, although the and role of different subpopulations in monitoring and outcome is not clear.
Rafael Alfaro, Isabel Legaz, Gema González-Martínez, Víctor Jimenez-Coll, Helios Martínez-Banaclocha, José Antonio Galián, Carmen Botella, Jesús de la Peña-Moral, María Rosa Moya-Quiles, José Antonio Campillo, Alfredo Minguela, Santiago Llorente, Manuel Muro   +12 more
doaj   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Comparison of three clinical scoring tools for bronchiolitis to predict the need for respiratory support and length of stay in neonates and infants up to three months of age

Frontiers in Pediatrics, 2023
BackgroundBronchiolitis severity can be assessed using different clinical scores. Some of the most used are the Wang Bronchiolitis Severity Score (WBSS), the Kristjansson Respiratory Score (KRS), and the Global Respiratory Severity Score (GRSS ...
Domenico Umberto De Rose, Chiara Maddaloni, Ludovica Martini, Annabella Braguglia, Andrea Dotta, Cinzia Auriti   +5 more
doaj   +1 more source

Arterial Spin‐Labeling MRI at the Cortical‐CSF Interface: A Novel Biomarker in Alzheimer Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background/Objective Arterial spin‐labeling (ASL) MRI can measure perfusion signal adjacent to CSF spaces and may provide information regarding CSF‐adjacent water transport physiology. We developed an automated pipeline to extract cortical‐CSF interface (IF) perfusion for comparison between Alzheimer disease (AD) and cognitively normal ...
Mona Asghariahmadabad, Pouya Metanat, Michael Thomas, Luke W. Bonham, Tyson Lam, Mehmet Kurt, Hong Nguyen, Tara Ellingson, Mauro Zucchelli, Stefano Casagranda, Quin Lu, Andreas M. Rauschecker, Leo Sugrue, Luis E. Savastano, Christopher P. Hess, Kamalini Ranasinghe, S. Andrew Josephson, Bruce L. Miller, Jennifer S. Yokoyama, Gil D. Rabinovici, Peter A. Ljubenkov, Lawren VandeVrede, Kambiz Nael   +22 more
wiley   +1 more source

Clinical Validation of Artificial Intelligence (AI)‐based Cartilage Segmentation Predicting Knee Replacement

Arthritis Care &Research, Accepted Article.
Objective For cartilage morphology to serve as a scalable endpoint in clinical trials, analyses should be performed automatically without human interaction. To clinically validate artificial intelligence (AI)‐based analysis, we studied cartilage loss from MRI prior to knee replacement.
Felix Eckstein, David J. Hunter, C. Kent Kwoh, Wolfgang Wirth   +3 more
wiley   +1 more source

Simple yet (more?) effective. Venous thromboembolism risk assessment model for germ cell tumour patients receiving first‐line chemotherapy

Cancer Medicine, 2023
Background Germ cell tumours (GCT) are highly curable malignancies. Venous thromboembolism (VTE) is a serious complication, needing better risk assessment models (RAM).
Wojciech Michalski, Grażyna Poniatowska, Joanna Jońska‐Gmyrek, Agnieszka Żółciak‐Siwińska, Inga Zastawna, Artur Lemiński, Anna Macios, Michał Jakubczyk, Tomasz Demkow, Paweł Wiechno   +9 more
doaj   +1 more source