Results 291 to 300 of about 260,030 (390)

Top‐Down Proteomics: Why and When?

PROTEOMICS, EarlyView.
ABSTRACT Manifold biological processes at all levels of transcription and translation can lead to the formation of a high number of different protein species (i.e., proteoforms), which outnumber the sequences encoded in the genome by far. Due to the large number of protein molecules formed in this way, which span an enormous range of different ...
Philipp T. Kaulich, Andreas Tholey
wiley   +1 more source

KRAS mutation promotes immune escape of lung adenocarcinoma via ZNF24/SLC7A5/PD-L1 axis. [PDF]

BMC Cancer
Li L, Feng Q, Jiang Y, Yang L, Fang H, Xu W, Wang Y, Pan X, Yang J.   +8 more
europepmc   +1 more source

Exploring relationships between tumor mutation burden with immunity and prognosis in lung adenocarcinoma based on weighted gene co‐expression network analysis

Precision Medical Sciences, EarlyView.
This study reveals that high TMB in lung adenocarcinoma correlates with better survival prognosis and lower immune/stromal scores. Through WGCNA and consensus clustering, we identify two LUAD subtypes with distinct prognoses and mutation frequencies, offering novel insights for immunotherapy response prediction and prognosis stratification.
Haiyong Wu, Jinzhuo Ren, Zhipeng Gong, Yan Zhang, Hua Zhang, Weikang Chen, Chenyang Zhao, Tao Fang   +7 more
wiley   +1 more source

KRAS G12C Inhibition in Solid Tumors: Biological Breakthroughs, Clinical Evidence, and Open Challenges. [PDF]

Cancers (Basel)
Vitiello PP, Valsecchi AA, Duregon E, Di Celle PF, Cassoni P, Papotti M, Bardelli A, Di Maio M.   +7 more
europepmc   +1 more source

ClusterNet: Classifying Single‐Molecule Localization Microscopy Datasets with Graph‐Based Deep Learning of Supracluster Structure

Small Science, EarlyView.
ClusterNet is a graph‐based deep learning pipeline for classifying single‐molecule localization microscopy (SMLM) data. It acts directly on point‐cloud localization data from a field of view of any size, using features of individual clusters of localizations together with their spatial arrangement.
Oliver Umney, Hayley Slaney, Christopher J. M. Williams, Philip Quirke, Michelle Peckham, Alistair P. Curd   +5 more
wiley   +1 more source

Targeting TGF-β-Smad2/3-JNK1-mediated SIRT1 activity overcomes the chemoresistance of KRAS mutation lung cancer. [PDF]

Exp Mol Med
Shin DH, Choi M, Han C, Kim SS.
europepmc   +1 more source

Loss of Integrin α1β1 Ameliorates Kras-Induced Lung Cancer

, 2008
Ines Macias‐Perez, Corina M. Borza, Xiwu Chen, Xuexian Yan, María Raquel Ibáñez, Glenda Mernaugh, Lynn M. Matrisian, Roy Zent, Ambra Pozzi   +8 more
openalex   +1 more source

Bioengineered Extracellular Vesicles in Emerging Cancer Vaccine Platforms

Small Science, EarlyView.
This review highlights recent advances in engineering extracellular vesicles (EVs) as next‐generation cancer vaccines. It outlines their biological roles and antigen‐presenting capacity, explores key strategies for antigen loading and delivery optimization, and summarizes preclinical and clinical applications using EVs from diverse immune and tumor ...
Wonkyung Ahn, Yeram Lee, Gi‐Hoon Nam, Jae Bem You, Eun Jung Lee   +4 more
wiley   +1 more source

Colorectal cancer tumor phenotypes associated with <i>KRAS</i>, <i>NRAS</i>, and <i>BRAF</i> hot-spot mutations. [PDF]

World J Gastrointest Pathophysiol
Abdelgadir O, Kuo YF, Khan MF, Okorodudu AO, Cheng YO, Dong J.   +5 more
europepmc   +1 more source

PCN17 ESTIMATING THE COST SAVINGS FROM THE INTRODUCTION OF KRAS TESTING IN THE MANAGEMENT OF METASTATIC COLORECTAL CANCER (MCRC) PATIENTS RECEIVING PANITUMUMAB IN GREECE

, 2008
V Papagianopoulou, A Christodoulopoulou, A. Bracco, I Yfantopoulos   +3 more
openalex   +1 more source