Results 321 to 330 of about 260,030 (390)

Exploring exosome profiling via CytoFLEX Nano flow cytometer: Approaches and applications

VIEW, EarlyView.
This study evaluated CytoFLEX Nano flow cytometer's exosome detection performance, comparing it with traditional CytoFLEX in sensitivity, repeatability, and fluorescence labeling. Notably, the CytoFLEX Nano demonstrates distinct advantages: enhanced sensitivity, improved selectivity, and expanded applicability.
Li Cao, Hui Wang, Jiaqi Zhu, Wen Li, Lin Han, Zhuanzhuan Wang, Xiaofei Wang, Bo Guo, Jiangbo Ding, Dongdong Tong, Chen Huang   +10 more
wiley   +1 more source

PRMT5 Inhibition as a Potential Strategy for KRAS Mutant CRC: Downstream Mediators of the PRMT5-KRAS Crosstalk. [PDF]

Curr Issues Mol Biol
Spivak M, Pahmer M, Delrahimnia D, Sapir T, Shifteh D.   +4 more
europepmc   +1 more source

Organoid‐based novel technology for antitumor drug screening

VIEW, EarlyView.
Organoids represent a cutting‐edge research model that closely mimics in vivo organ physiology, making them highly valuable for tumor immunotherapy drug screening. This review explores the integration of organoids with advanced technologies, such as gene editing, 3D bioprinting, and AI, highlighting novel fusion platforms and their applications.
Yu Su, Yuan Chen, Guanning Wei, Yihai Shi   +3 more
wiley   +1 more source

Structural basis for LZTR1 recognition of RAS GTPases for degradation. [PDF]

Science
Dharmaiah S, Bonsor DA, Mo SP, Fernandez-Cabrera A, Chan AH, Messing S, Drew M, Vega M, Nissley DV, Esposito D, Castel P, Simanshu DK.   +11 more
europepmc   +1 more source

miRNA Profiling of Cholesteatoma‐Derived Exosomes Reveals Exosomal miR‐223‐3p and miR‐142‐5p as Potential Biomarkers for Acquired Middle Ear Cholesteatoma

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objectives Acquired cholesteatoma is an abnormal and invasive growth of keratinized squamous epithelial cells in the middle ear. The study aims to explore the role of exosomal miRNAs in the pathogenesis of acquired cholesteatoma and their potential in clinical application.
Qi Tang, Meng‐Yao Xie, Shu Wang, Zhi‐Yuan Wu, Zhi‐Jin Han, Chen Li, Shu‐Yi Wang, Yuan Cao, Yu‐Run Chen, Bin Wang, Ying‐Ying Shang, Xiao‐Wu Huang, Hua Yang   +12 more
wiley   +1 more source

KRAS: the Achilles' heel of pancreas cancer biology. [PDF]

J Clin Invest
Drizyte-Miller K, Talabi T, Somasundaram A, Cox AD, Der CJ.   +4 more
europepmc   +1 more source

When Do Supply Chain Employees Feel Responsible for Proactively Engaging in Greening Behaviours?

British Journal of Management, EarlyView.
Abstract Employees in supply chain (SC) functions are increasingly assigned sustainability‐related responsibilities and expected to engage in green behaviours. While prior research distinguishes voluntary from required green behaviours, the SC context suggests that employees perceive varying degrees of voluntariness and obligation.
Savita Verma, Chee Yew Wong, Kerrie Unsworth   +2 more
wiley   +1 more source

Oncogenic driver mutations underlie the spatial tumour immune landscape of non-small cell lung cancer. [PDF]

Nat Commun
Hartner S, Abolfathi H, Rezanejad M, Liu B, Karimi E, Rogers D, Sorin M, Doré S, Desharnais L, Orain M, Enlow W, Gagné A, Wei Y, Bossé Y, Quail DF, Joubert P, Walsh LA.   +16 more
europepmc   +1 more source

Clinical Implications of KRAS Mutations in Lung Cancer Patients Treated with Tyrosine Kinase Inhibitors: An Important Role for Mutations in Minor Clones

, 2009
Antonio Marchetti, Michèle Milella, Lara Felicioni, Federico Cappuzzo, Luciana Irtelli, Maela Del Grammastro, Mariagrazia Sciarrotta, Sara Malatesta, Carmen Nuzzo, Giovanna Finocchiaro, Bruno Perrucci, Donatella Carlone, Alain Gelibter, Anna Ceribelli, Andrea Mezzetti, Stefano Iacobelli, Francesco Cognetti, Fiamma Buttitta   +17 more
openalex   +1 more source

Determining the Survival Impact and Cost‐Effectiveness of Multi‐Gene Panel Sequencing in Metastatic Colorectal Cancer With Super Learning Approaches

Health Services Research, EarlyView.
ABSTRACT Objective To determine the effectiveness and cost‐effectiveness of multi‐gene panel sequencing compared to single‐gene KRAS testing for metastatic colorectal cancer (mCRC). Study Setting and Design British Columbia, Canada (BC) is a provincial single‐payer public healthcare system, and it was the first province to publicly reimburse multi‐gene
Emanuel Krebs, Deirdre Weymann, Howard J. Lim, Stephen Yip, Dean A. Regier   +4 more
wiley   +1 more source