Results 331 to 340 of about 260,030 (390)

Single-molecule imaging quantifies oncogenic KRAS dynamics for enhanced accuracy of therapeutic efficacy assessment. [PDF]

iScience
Yokoi R, Mori T, Hirosawa KM, Kondo R, Taguchi T, Matsuhashi N, Suzuki KGN.   +6 more
europepmc   +1 more source

Regulation of the MAPK/ERK Pathway by miRNA‐27b in Gastric Cancer: Diagnostic Implications and Therapeutic Potential of Aloin

Asia-Pacific Journal of Clinical Oncology, EarlyView.
ABSTRACT Background Globally, gastric cancer (GC) ranks as the fourth most deadly and fifth most prevalent kind of cancer. Appropriate treatment methods, precise etiology, and molecular processes of GC are still unclear. Methods In silico and quantitative real‐time reverse transcription polymerase chain reaction (qRT‐PCR)‐based expression of miRNA‐27b ...
Yang Dehuo, Wang Ying, Cao Lin
wiley   +1 more source

Coinhibition of the MEK/RTK pathway has high therapeutic efficacy in KRAS-mutant non-small cell lung cancer. [PDF]

Signal Transduct Target Ther
Lu J, Hu M, Zhao Y, Chu T, Zhang W, Zhou Y, Cai X, Wu J, Hu L, Shi C, Xiong L, Gu A, Wang H, Zhang Y, Lou Y, Zhong R, Gao Z, Liu H, Zhou C, Wu Y, Zhu L, Zhong H, Ji H, Han B.   +23 more
europepmc   +1 more source

Advances and Future Perspectives for the Management of Non‐Small Cell Lung Cancer in Australia: A Narrative Review

Asia-Pacific Journal of Clinical Oncology, EarlyView.
Lung cancer remains Australia's leading cause of cancer death. With new screening and evolving therapies, equitable access and workforce readiness are essential. This review discusses current and emerging treatments for NSCLC in Australia, clinical trials underway, and future directions in delivering optimal, accessible care nationwide.
Lauren Julia Brown, Graham Meredith, Bo Gao, Pei Ding, Harriet Gee, Inês Pires da Silva, Adnan Nagrial, Eric Hau   +7 more
wiley   +1 more source

Molecular characterization and prognostic implications of KRAS mutations in pancreatic cancer patients: insights from multi-cohort analysis. [PDF]

NPJ Precis Oncol
Jiang Y, Mai G, Zhao X, Tang M, Yang P, Cheng Q, Tian H, Niu Z, Wang X, Wang J, Zhu Y, Li J, Gong Z, Zhang D, Xu H.   +14 more
europepmc   +1 more source

Proteomic profiling of porcine seminal extracellular vesicles reveals potential in vivo fertility biomarkers

Andrology, EarlyView.
Abstract Background Predicting male fertility in farm animals remains a challenge. Seminal plasma (SP) contains a high amount of heterogeneous seminal extracellular vesicles (sEVs), believed involved in reproductive processes and maybe key to understanding male fertility.
Isabel Barranco, Pablo Martínez‐Díaz, Ana Parra, María José Martínez‐Alborcia, Xiomara Lucas, Heriberto Rodríguez‐Martínez, Jordi Roca   +6 more
wiley   +1 more source

KRAS and NRAS Mutations in Relation to Microsatellite Status in Colorectal Cancer: A Single-Center Study From Romania. [PDF]

Cureus
Abrudan R, Abrudan L, Camarasan A, Camarasan O, Burta O, Pop O.   +5 more
europepmc   +1 more source

Spatial transcriptomics mapping of immune cell and TGFβ signalling pathway heterogeneity in testicular germ cell tumours

Andrology, EarlyView.
Abstract Background Testicular germ cell tumours (TGCTs) are amongst the most common malignancies in young men, and their incidence is increasing worldwide. Tissue heterogeneity hampers efforts to understand how TGCT precursors (termed germ cell neoplasia in situ; GCNIS) emerge and progress, restricting elucidation of new strategies for diagnosis and ...
Sarah C. Moody, Daniela Fietz, Benedict Nathaniel, Mark Frydenberg, Ben Tran, Hans‐Christian Schuppe, Kate L. Loveland   +6 more
wiley   +1 more source

Research progress on predicting KRAS gene mutations in colorectal cancer by combining radiomics and multimodal medical imaging. [PDF]

Front Oncol
Ai M, Li L, Fan S, He C, Guo Y, He Y.
europepmc   +1 more source

Monitoring of measurable residual disease by next‐generation sequencing in patients with acute myeloid leukaemia

British Journal of Haematology, EarlyView.
Summary Measurable residual disease (MRD) is a strong prognostic factor in acute myeloid leukaemia (AML). Next‐generation sequencing (NGS) offers promise but must distinguish true signal from background. We assessed MRD in 98 adult AML patients in first complete remission after intensive chemotherapy using a duplex unique molecular identifier (UMI ...
Augustin Boudry, Laure Goursaud, Delphine Lebon, Florent Dumezy, Véronique Harrivel, Alexandre Boue‐Raguet, Romane Joudinaud, Alice Marceau‐Renaut, Sandrine Geffroy, Carine Hauspie, Jan Brijs, Laurène Fenwarth, Céline Berthon, Jean‐Pierre Marolleau, Martin Figeac, Claude Preudhomme, Nicolas Duployez   +16 more
wiley   +1 more source