Results 191 to 200 of about 16,315 (258)

A Comprehensive 19F NMR Framework for Fragment‐Based Drug Discovery: The Validated Screening Library OpenFL600 and Efficient Affinity Ranking by CSAR

Angewandte Chemie, EarlyView.
NMR screening is a powerful method for hit detection in drug‐discovery. We designed and validated the OpenFL600 19F$^{19}{\rm F}$ NMR library to probe diverse targets, including RNA, GPCRs, kinases, and proteases. This library yields target‐specific ligands without generating promiscuous binders.
Simon H. Rüdisser, Gabriela Stadler, Giacomo Padroni, Daria Barbash, Marco M. Ruckstuhl, Nils Lorz, Christina Jordan, Sarah Skibinski, Timo T. Stühlinger, Sarah E. Kratzwald, Katharina M. Siess, Sven Brüschweiler, Gerald Platzer, Antoine Cléry, Robert Konrat, Frédéric H.‐.T. Allain, Alvar D. Gossert   +16 more
wiley   +1 more source

Regional variation in clinical-trial risks: a large-scale analysis of 585 clinical trials. [PDF]

BMJ Open
de Viron S, Young S, Trotta L, Buyse M.
europepmc   +1 more source

The <i>R</i> = 1 threshold can misclassify epidemic stability. [PDF]

Commun Phys
Parag KV, Santillana M, Cori A, Obolski U.   +3 more
europepmc   +1 more source

Kri in derivati

Obzornik zdravstvene nege, 1972
openaire   +1 more source

Corrigendum to: Reevaluating the imaging definition of tumor progression: perfusion MRI quantifies recurrent glioblastoma tumor fraction, pseudoprogression, and radiation necrosis to predict survival. [PDF]

Neuro Oncol
europepmc   +1 more source

Penicillin Allergy Delabeling: Provider Knowledge, Practice Patterns, and Barriers Among Internal Medicine Residents in a Large Urban Community Teaching Hospital. [PDF]

Cureus
Aloyan T, Salimova D, Antonov E, Chandra G, McGrath K.   +4 more
europepmc   +1 more source

Intraoperative margin assessment using fluorescence confocal microscopy during robot-assisted radical prostatectomy: a first experience. [PDF]

BJU Int
de Angelis M, Beatrici E, Penaranda NR, Frego N, Resca S, Vecchio E, Barretta A, Ticonosco M, Brancelli C, Cavarra V, Guidotti A, Pepillo F, Prata F, Carl N, Barletta F, Cei F, De Naeyer G, Lambert E, Steen KV, De Groote R, Mottrie A.   +20 more
europepmc   +1 more source

Pleuropulmonary Blastoma and Diagnostic Pitfalls: A Report from the International Pleuropulmonary Blastoma/DICER1 Registry. [PDF]

Arch Pathol Lab Med
Nelson AT, Schultz KAP, Harris AK, Mei L, Nickel AJ, Stewart DR, Harney LA, Dishop MK, Pogoriler J, Olson DR, Messinger YH, Hill DA, Dehner LP.   +12 more
europepmc   +1 more source

Der Kris

openaire   +1 more source