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Immunotherapy for KSHV-associated diseases
Current Opinion in Virology, 2022Kaposi sarcoma herpesvirus (KSHV)-associated diseases (Kaposi sarcoma, multicentric Castleman disease, primary effusion lymphoma, and KSHV inflammatory cytokine syndrome) are associated with immune suppression and dysregulation and loss of KSHV-specific immunity.
Kathryn, Lurain +2 more
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Current Oncology Reports, 2005
Kaposi's sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV-8), has been linked to several malignancies in humans. KSHV is the etiologic agent associated with the development of Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman's disease (MCD). KSHV is a double-stranded DNA virus that has been
Blossom Damania, Emily L. Wong
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Kaposi's sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV-8), has been linked to several malignancies in humans. KSHV is the etiologic agent associated with the development of Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman's disease (MCD). KSHV is a double-stranded DNA virus that has been
Blossom Damania, Emily L. Wong
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KSHV Genome Replication and Maintenance in Latency.
Advances in Experimental Medicine and Biology, 2018Kaposi's sarcoma-associated herpesvirus (KSHV), also called human herpesvirus-8 (HHV-8), is the eighth human herpesvirus found by Yuan Chang and Patrick Moore, 1992. It is a Rhadinovirus belonging to the gamma herpesvirus subfamily. As known for many gamma herpesviruses, KSHV is also well-correlated to several cancer formations such as Kaposi's sarcoma,
K. Ueda
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KSHV infection of B-cell lymphoma using a modified KSHV BAC36 and coculturing system
The Journal of Microbiology, 2012Kaposi's sarcoma-associated herpesvirus (KSHV) is the causative agent of two B cell lymphoproliferative diseases, namely primary effusion lymphoma (PEL) and multicentric Castleman's disease (MCD). KSHV infection of B cell lymphoma in vitro has been a long-standing battle in advancing human KSHV biology.
Hyojeung Kang, Hyosun Cho
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KSHV flicks the metabolic switch [PDF]
Nature Reviews Microbiology, 2014 Yogev et al. show that KSHV-encoded miRNAs induce the Warburg effect in latently infected cells and that it is important to maintain viral latency.
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2008
Kaposi’s sarcoma-associated herpesvirus (KSHV) has been consistently implicated in the pathogenesis of Kaposi’s sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman’s disease (MCD). The hallmark of KSHV infection is to establish life-long persistency that has imposed enormous pressure on this virus to escape host immune recognition.
Jae U. Jung +4 more
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Kaposi’s sarcoma-associated herpesvirus (KSHV) has been consistently implicated in the pathogenesis of Kaposi’s sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman’s disease (MCD). The hallmark of KSHV infection is to establish life-long persistency that has imposed enormous pressure on this virus to escape host immune recognition.
Jae U. Jung +4 more
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KSHV-like herpesviruses in chimps and gorillas
Nature, 2000Among the herpesviruses1, KSHV (Kaposi's-sarcoma-associated herpesvirus) is the human prototype of the rhadinovirus genus2. Rhadinoviruses (or γ2-herpesviruses) are found in several animal species, including New and Old World monkeys, but not in the great apes3,4,5.
Antoine Gessain +5 more
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Rhadinoviruses: KSHV and Associated Malignancies [PDF]
, 2011 Kaposi’s Sarcoma Herpesvirus (KSHV), discovered in 1994, is the only known Rhadinovirus (γ2-herpesvirus) to naturally infect humans. In addition to Kaposi’s Sarcoma (KS), one of the most common HIV-associated malignancies, KSHV is strongly associated with two rare lymphoproliferative disorders, namely, primary effusion lymphoma (PEL) and the ...
Thomas F. Schulz, Susann Santag
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2007
Human infection by KSHV is associated with the development of at least three proliferative disorders: Kaposi’s sarcoma (KS), primary effusion lymphoma (PEL) and a subset of multicentric Castleman’s disease (MCD). In keeping with the classification of KSHV as a lymphotropic (γ2) herpesvirus, two of these (PEL and MCD) are primary disorders of the B cell
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Human infection by KSHV is associated with the development of at least three proliferative disorders: Kaposi’s sarcoma (KS), primary effusion lymphoma (PEL) and a subset of multicentric Castleman’s disease (MCD). In keeping with the classification of KSHV as a lymphotropic (γ2) herpesvirus, two of these (PEL and MCD) are primary disorders of the B cell
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