Results 41 to 50 of about 1,660 (149)

Amide proton transfer weighted imaging combined with dynamic contrast-enhanced MRI in predicting lymphovascular space invasion and deep stromal invasion of IB1-IIA1 cervical cancer

Frontiers in Oncology, 2022
ObjectivesTo investigate the value of amide proton transfer weighted (APTw) imaging combined with dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in predicting intermediate-risk factors of deep stromal invasion (DSI) and lymphovascular ...
Qingling Song, Shifeng Tian, Changjun Ma, Xing Meng, Lihua Chen, Nan Wang, Liangjie Lin, Jiazheng Wang, Qingwei Song, Ailian Liu   +9 more
doaj   +1 more source

Current Advances of Treatments, Therapeutic Targets, Biomarkers, Novel Drugs, and Machine Learning for Hypopharyngeal Squamous Cell Carcinoma

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Hypopharyngeal squamous cell carcinoma (HSCC) is an aggressive subtype of head and neck squamous cell carcinoma with insidious onset, early metastasis, and dismal prognosis. Conventional multimodal therapy achieves limited survival benefit, highlighting an urgent need for refined precision strategies.
Ce Li, Rui Guan, Rui‐Jie Jiao, Zhi‐Jie Bi, Yang Fu, Yin Wang, Chen‐Yang Xu, Ye Qian, Ran Wei, Sheng‐Da Cao, Wen‐Ming Li, Dong‐Min Wei, Da‐Peng Lei   +12 more
wiley   +1 more source

Correlation of volume transfer coefficient K^trans with histopathologic grades of gliomas [PDF]

Journal of Magnetic Resonance Imaging, 2012
AbstractPurpose:To evaluate the roles of dynamic contrast‐enhanced magnetic resonance imaging (DCE‐MRI) and optimum tracer kinetic parameters in the noninvasive grading of the glial brain tumors with histopathological grades (I–IV).Materials and Methods:Twenty‐eight patients with histopathologically graded gliomas were imaged.
Na, Zhang, Lijuan, Zhang, Bensheng, Qiu, Li, Meng, Xiaoyi, Wang, Bob L, Hou   +5 more
openaire   +2 more sources

The nitty‐gritty of vascular permeability in cancer: targeting blood endothelium to control metastases

British Journal of Pharmacology, EarlyView.
Blood vascular permeability is a hallmark of cancer and acts as an active driver of metastatic dissemination. Metastasis accounts for the vast majority of cancer deaths, yet most work has focussed on tumour‐intrinsic traits and angiogenesis, while the specific contribution of endothelial barrier regulation to intravasation and extravasation remains ...
Pierre Boucher, Mérone Da Costa Oliveira, Adrien Levesque, Alexandre Rutault, Patrick Savoyaud, Nicolas Bréchot, Stéphane Germain   +6 more
wiley   +1 more source

Targeting KRAS for cancer therapy

British Journal of Pharmacology, EarlyView.
In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia, Ruonan Liu, Tonia A. Adamide, Isis E. Fernandez, Georgios T. Stathopoulos   +4 more
wiley   +1 more source

Brain Clearance of Contrast Agent in Intravenous DCE‐MRI Is Measurable and Cannot Be Explained by Clearance Across the BBB Alone

Magnetic Resonance in Medicine, Volume 96, Issue 5, Page 2309-2320, November 2026.
ABSTRACT Purpose To determine the feasibility of measuring brain clearance of gadolinium contrast agent using standard intravenous DCE‐MRI acquisitions and evaluate the contribution of blood–brain barrier (BBB) and non‐BBB clearance routes. Methods Uptake and extended Tofts models were fit to DCE‐MRI data from people with Parkinson's disease, post ...
Martin Kozár, Ioana‐Emilia Mosneag, Sarah Al‐Bachari, Igor Chernyavsky, Geoff J. M. Parker, Hervé Boutin, Laura M. Parkes, Ingo Schiessl, Ben R. Dickie   +8 more
wiley   +1 more source

Evaluating differential nanoparticle accumulation and retention kinetics in a mouse model of traumatic brain injury via Ktrans mapping with MRI [PDF]

Scientific Reports, 2019
AbstractTraumatic brain injury (TBI) is a leading cause of injury-related death worldwide, yet there are no approved neuroprotective therapies that improve neurological outcome post-injury. Transient opening of the blood-brain barrier following injury provides an opportunity for passive accumulation of intravenously administered nanoparticles through ...
Hunter A. Miller, Alexander W. Magsam, Aria W. Tarudji, Svetlana Romanova, Laura Weber, Connor C. Gee, Gary L. Madsen, Tatiana K. Bronich, Forrest M. Kievit   +8 more
openaire   +2 more sources

In Vivo Correlation of Glucose Metabolism, Cell Density and Microcirculatory Parameters in Patients with Head and Neck Cancer: Initial Results Using Simultaneous PET/MRI. [PDF]

PLoS ONE, 2015
To demonstrate the feasibility of simultaneous acquisition of 18F-FDG-PET, diffusion-weighted imaging (DWI) and T1-weighted dynamic contrast-enhanced MRI (T1w-DCE) in an integrated simultaneous PET/MRI in patients with head and neck squamous cell cancer (
Matthias Gawlitza, Sandra Purz, Klaus Kubiessa, Andreas Boehm, Henryk Barthel, Regine Kluge, Thomas Kahn, Osama Sabri, Patrick Stumpp   +8 more
doaj   +1 more source

Spatiotemporal Dynamics of Cerebral Vascular Permeability in Type 2 Diabetes-Related Cerebral Microangiopathy

Frontiers in Endocrinology, 2022
AimsDiabetes-related cerebral microangiopathy can manifest as cerebral small vessel disease (CSVD) and exhibit cognitive decline. To find the early change of function in advance, this study examined the spatiotemporal dynamics of cerebral vascular ...
Ying-Chen Chen, Ying-Chen Chen, Bing-Ze Lu, Yu-Chen Shu, Yuan-Ting Sun, Yuan-Ting Sun   +5 more
doaj   +1 more source

Demarcation of the operating renal cortex in a coronal reformation of the Ktrans maps (A).

, 2014
Cortex volume, calculated with a volume-program by setting upper and lower limits (upper limit 300 mL/100 mL/min, lower limit 80 mL/100 mL/min, volume 59 mL, mean Ktrans 98±10 (B). r2 map shows linearity of the Patlak fit in % (C).
Andreas Helck (533573), Ulf Schönermarck (533574), Dirk Andrè Clevert (533578), Mike Notohamiprodjo (88029), Konstantin Nikolaou (394756), Maximilian Reiser (266508), Antje Habicht (367049), Manfred Stangl (533575), Christian la Fougère (533577), Christoph Becker (266511), Ernst Klotz (533576)   +10 more
core   +1 more source