Results 161 to 170 of about 245,162 (297)

Prophylactic protocol for cerebral infarction after left upper lobectomy and prospective analysis of pulmonary vein stump thrombosis. [PDF]

J Thorac Dis
Matsumoto A, Yutaka Y, Sakanoue I, Kayawake H, Sumitomo R, Nishikawa S, Tanaka S, Nakajima D, Menju T, Muramatsu Y, Hidaka Y, Date H.   +11 more
europepmc   +1 more source

Macrophage TRIM21 Inhibition Ameliorates Murine Acute Pancreatitis via PHB2‐Mediated Mitochondrial Stabilization

Advanced Science, EarlyView.
Macrophage‐derived TRIM21 drives the progression of AP via ubiquitin‐proteasome‐mediated degradation of PHB2, leading to impaired PHB2‐mediated mitophagy. Therefore, accumulation of cytosolic mtDNA hyperactivates the cGAS‐STING signaling axis, thereby amplifying inflammatory cascades.
Yansong Xu, Yuansong Sun, Xin Zhou, Kai Song, Chunlin Yin, Zhaohua Wang, Fei Xie, He Li   +7 more
wiley   +1 more source

Efficacy of protocol-based pharmacotherapy management in switching of antibiotic administration routes and dose adjustment based on renal function: a before-after study. [PDF]

J Pharm Health Care Sci
Sato Y, Takatani Y, Nakagawa S, Katada Y, Tsuchido Y, Sugimoto M, Kimata M, Saigo M, Tsuda M, Ohtsuru S, Terada T.   +10 more
europepmc   +1 more source

Flexible Global Carbon Pricing: A Backward-Compatible Upgrade for the Kyoto Protocol [PDF]

The Kyoto Protocol’s approach of assigning emission targets, or “caps,” promises certainty that it cannot deliver, because it exacerbates problems with international cooperation and commitment.
Steven Stoft
core  

A BioLiving Periosteum Evokes Centripetal Regeneration in Challenging Bone Defects

Advanced Science, EarlyView.
Large bone defects often suffer from insufficient central healing. This study engineers a BioLiving periosteum that mimics the native structure. It sequentially delivers remote chemical cues and contact physical cues in a signaling‐relay manner, effectively recruiting and guiding endogenous cells toward the defect center.
Yang Shi, Nian Liu, Jingyi Gu, Yinling Wang, Weiye Wang, Zhiwei Ke, Mingjun Xie, Wenjing Jin, Weicheng Kong, Jue Shi, Hui Pan, Yong He, Zhijian Xie   +12 more
wiley   +1 more source

Non-nutritive sweeteners attenuate reinforced cephalic phase insulin release and impair glucose tolerance in mice. [PDF]

J Physiol Sci
Otsuki T, Okihara K, Nomura K, Matsui S, Taruno A, Sasaki T.   +5 more
europepmc   +1 more source

Context‐Dependent Role of GDF15: GDF15+ Tumor‐Associated Macrophages Suppress OSCC Progression by Enhancing Phagocytosis

Advanced Science, EarlyView.
This study identifies GDF15+ TAMs as a cell subset mediating tumor regression after immunotherapy. Macrophage‐intrinsic GDF15 enhances phagocytosis and antigen cross‐presentation to CD8+ T cells through the NF‐κB signaling pathway, thereby inhibiting tumor progression.
Xinyu Zhou, Zhihang Zhou, Houyu Ju, Chaoyang Guo, Fangxing Zhu, Yiyi Zhang, Xu Chen, Tongchao Zhao, Laiping Zhong, Jingzhou Hu   +9 more
wiley   +1 more source

Conventional Versus Underwater Endoscopic Mucosal Resection for Superficial Non-Ampullary Duodenal Epithelial Tumors ≤ 20 mm: Study Protocol for a Multicenter Randomized Controlled Trial (D-CURE Trial). [PDF]

Methods Protoc
Yoshida M, Hatta W, Nakamura T, Nakaya N, Shichijo S, Tanaka Y, Kanzaki H, Hirasawa K, Oda I, Hirose T, Kato M, Takizawa K, Toya Y, Hikichi T, Sawai H, Yoshida N, Dohi O, Masamune A, Abe S, Yano T, D-CURE Trial Group.   +20 more
europepmc   +1 more source

Greenhouse gas emissions and the role of the Kyoto Protocol [PDF]

Our study empirically investigates the effects of the Kyoto Protocol’s quantified emission limitation or reduction commitments on various greenhouse gas (GHG) emissions such as CO2, CH4, N2O and other greenhouse gases, consisting of HFCs, PFCs and SF6 ...
Iwata, Hiroki, Okada, Keisuke
core   +1 more source

Adipocyte‐Derived Exosomal miR‐5099 Mitigates M1 Macrophage Polarization and Adipose Inflammation via c‐Met/NF‐κB Axis to Improve Metabolic Health

Advanced Science, EarlyView.
Celastrol upregulates adipocyte‐derived exosomal miR‐5099, suppressing the macrophage c‐Met/NF‐κB axis to mitigate pro‐inflammatory M1 polarization and adipose inflammation. These miR‐5099‐enriched exosomes also act as endocrine signals targeting the liver, muscle, and adipocytes to significantly enhance systemic insulin sensitivity.
Ping Tang, Lixin Tai, Hongxia Xu, Dongliang Zhu, Jiajia Li, Hao Feng, Jinghui Cui, Shuhai Lin, Li‐jun Di, Li Wang   +9 more
wiley   +1 more source