Results 161 to 170 of about 1,710,062 (294)

NSD2 Coordinates the Neurogenic‐to‐Gliogenic Transition via H3K36me2‐Dependent Activation of the EGFR‐ERK Pathway

Advanced Science, EarlyView.
NSD2 coordinates the neurogenic‐to‐gliogenic transition in the developing neocortex through H3K36me2‐dependent activation of EGFR–ERK signaling. Loss of NSD2 disrupts astroglial and oligodendroglial development, whereas ERK activation rescues gliogenic defects in vitro and in vivo.
Hanxue Chen, Mengyuan Li, Lin Hou, Bin Yin, Boqin Qiang, Ran Gao, Pengcheng Shu, Xiaozhong Peng   +7 more
wiley   +1 more source

THE COST OF THE KYOTO PROTOCOL TO U.S. CROP PRODUCTION: MEASURING CROP PRICE, REGIONAL ACREAGE, WELFARE, AND INPUT SUBSTITUTION EFFECTS [PDF]

This study analyzes the impact of implementing carbon permit trading considered under the Kyoto Protocol, and the subsequent expected increase in energy and resource prices on U.S. crop production.
Konyar, Kazim, Howitt, Richard E.
core  

Protocol for in vitro chemoenzymatic synthesis of thiazole-containing macrocyclic peptides via ribosomal incorporation of thioamides. [PDF]

STAR Protoc
Saito A, Goto Y.
europepmc   +1 more source

SPSB1 Promotes Subcutaneous Adipose Hyperplasia in Facial Port‐Wine Stains by Controlling HDAC1 Degradation and Stability Through Two Distinct Proteolytic Pathways

Advanced Science, EarlyView.
In PWS‐ASPCs, FOSL1 drives the expression of SPSB1. SPSB1, as part of the ESC complex, further binds to HDAC1 and promotes K29‐linked and K48‐linked polyubiquitination of HDAC1. These modifications facilitate the degradation of HDAC1 through the ALP and UPS pathways, respectively.
Hongrui Chen, Bin Sun, Yajing Qiu, Chen Hua, Xiaoxi Lin, Wei Gao   +5 more
wiley   +1 more source

Estimates of the Costs of Kyoto-Marrakesh versus the McKibbin-Wilcoxen Blueprint [PDF]

In this paper we update our earlier estimates of the cost of the Kyoto Protocol using the G-Cubed model, taking into account the new sink allowances from recent negotiations as well as allowing for multiple gases and new land clearing estimates.
Warwick J. McKibbin, Peter J. Wilcoxen
core  

Estimation of effective half-life and lesion-specific kinetics in I-131 therapy for differentiated thyroid cancer using dual-timepoint imaging. [PDF]

EJNMMI Phys
Iizuka Y, Nakashima R, Aizawa R, Kajisako M, Shioji M, Mitsumoto K, Itagaki K, Kawase S, Mizowaki T.   +8 more
europepmc   +1 more source

Kyoto Protocol [PDF]

, 2005
openaire   +2 more sources

A Second Pathogenic Protein, PolyGN2C‐iso2, Reveals a Dual‐Protein Pathology in Neuronal Intranuclear Inclusion Disease

Advanced Science, EarlyView.
This study reveals that NOTCH2NLC transcript variant 2 generates PolyGN2C‐iso2, an aggregating protein present within intranuclear inclusions of NIID patient tissues. A novel mouse model expressing PolyGN2C‐iso2 recapitulates white matter abnormalities and cognitive deficits, mechanistically linked to mitochondrial dysfunction. These findings support a
Kang Zhang, Wenhao Ma, Yi Zhou, Zhijie Wu, Pan Gao, Hongze Niu, Hongfei Tai, Tianyi Zhao, Zheyue Dong, Li Li, Yan Zhang, An Wang, Si Shen, Yueyang Li, Sifei Yu, Yan Peng, Wang Sheng, Xiaoyan Dong, Hua Pan, Kaibin Shi, Magdalena J. Koziol, Xiaobing Wu, Zaiqiang Zhang   +22 more
wiley   +1 more source

The Economics of a Lost Deal : Kyoto - The Hague - Marrakesh [PDF]

This paper examines prospects for compromise between competing perspectives on four key climate change issues: costs, level of domestic action, nvironmental integrity, and developing world involvement.
Frédéric Ghersi, Jean-Charles Hourcade
core  

Preventive effects of active Protocol-Based Pharmacotherapy Management for delirium in general wards of emergency department (aPBPM trial): study protocol for a single-center, randomized controlled trial {1a}. [PDF]

Trials
Takatani Y, Sato Y, Sugita N, Abe H, Yamane M, Yamanaka Y, Takeda M, Minami T, Terada T, Ohtsuru S.   +9 more
europepmc   +1 more source