Results 71 to 80 of about 2,241,424 (335)

Developing countries and the future of the Kyoto Protocol [PDF]

Developing countries will need to be involved if a future international agreement is to be effective in slowing climate change. Under the Kyoto Protocol’s first commitment period (2008-12), developing countries have not got emissions targets, and the ...
Frank Jotzo
core  

GATA4‐Driven Transcription of HtrA1 Promotes Cellular Senescence in Ménière's Disease and Age‐Related Audio‐Vestibular Dysfunction

Advanced Science, EarlyView.
This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang, Na Li, Yan Wang, Jing Zhang, Jiahui Liu, Lei Chen, Yongdong Song, Yurong Mu, Yuechen Han, Yafeng Lyu, Xiaofei Li, Hanyue Wang, Jing Wang, Yao Lu, Zhaomin Fan, Daogong Zhang, Haibo Wang   +16 more
wiley   +1 more source

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

The policy process on climate change

Journal of Forest Science, 2005
The United Nations Framework Convention on Climate Change accepted in 1992 at the Earth Summit in Rio de Janeiro provides principles and framework for cooperative international action on mitigating climate change.
Z. Sarvašová, A. Kaliszewski
doaj   +1 more source

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

RNA Helicase DDX21 Controls CD4+ T Cell Proliferation and Promotes Inflammatory Bowel Disease via Translational Control

Advanced Science, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang, Chen Kan, Xinhui Yang, Yajuan Hao, Xuemin Cai, Mei Yang, Qianqian Zhang, Zhengting Wang, Ning Jiang, Lei Wang, Hua‐Bing Li, Jing Zhou   +11 more
wiley   +1 more source

A methodology for analysing temporal changes of forest surface using aerial photos for the application of Kyoto protocol: a study case in Northern Italy

Forest@, 2006
According to art. 3.3 of the Kyoto Protocol, Italy, like other Parties included in Annex I, shall report the net changes in greenhouse gas emissions by sources and removals by sinks resulting from afforestation, reforestation and deforestation activities
Salvadori I, Pilli R, Anfodillo T
doaj  

What are the boundaries of the law on climate change? [PDF]

Zbornik Radova Pravnog Fakulteta u Nišu, 2019
The paper commences by evaluating the conception that the law on climate change includes an extremely wide range of issues whose delimitation cannot be precisely determined.
Todić Dragoljub
doaj  

Usefulness of Exercise for Home Blood Pressure Control in People with Diabetes: A Study Protocol for a Crossover Randomized Controlled Trial [Corrigendum]

Diabetes, Metabolic Syndrome and Obesity, 2022
Iwai K, Ushigome E, Yokota I, et al. Diabetes Metab Syndr Obes. 2020;13:4747–4753. The authors have advised there was an error in the Institutional Review Board’s protocol version number.
Iwai K, Ushigome E, Yokota I, Majima S, Nakanishi N, Hashimoto Y, Okada H, Senmaru T, Hamaguchi M, Asano M, Yamazaki M, Fukui M   +11 more
doaj  

How relevant to sub-Saharan Africa is the Kyoto Protocol?

Journal of Energy in Southern Africa, 2017
The African Recovery Journal once referred to it as, ‘an opportunity for African countries to attract new financing for their own sustainable development’. It was indeed waited for with much anticipation. In fact, today, it is readily observable that the
A B Sebitosi
doaj   +1 more source