Results 161 to 170 of about 24,487,241 (258)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Elucidating the Role of Aqueous Solvent and Cations in Selectivity of Cobalt-Porphyrin Catalyzed CO₂ Reduction Over Hydrogen Evolution. [PDF]

Chemphyschem
Zhuo L, Meijer EJ.
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Emergent cooperative superstructures via order-disorder kinetics in molecular intercalation superlattices. [PDF]

Sci Adv
Ueda T, Matsuoka H, Aoyagi S, Kitou S, Zhang Y, Kimura F, Hagiwara K, Sakano M, Iwagaki T, Nakamura Y, Ishizaka K, Machida T, Suda M, Arima TH, Kanazawa N.   +14 more
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Spatial Mapping of the Precancer-to-Cancer Transition in Breast and Prostate. [PDF]

Cancer Discov
Storrs E, Mo CK, Chou WH, Bhatt G, Chen S, Wei X, Houston A, Karpova A, Jayasinghe RG, Lal P, Bayguinov P, Herndon JM, Li X, Anjum Simin F, Fang X, Wendl MC, Liu X, Zheng H, Davies SR, Wang JT, Shinkle A, Fulton RS, Ponce J, Heinz M, Head R, Chen, Zhao Y, Fenyo D, Li YE, Ma CX, Aft R, Reimers MA, Kim AH, Puram SV, Fitzpatrick JAJ, Shoghi KI, Figenshau RS, Ademuyiwa FO, Ju T, Colditz GA, Drake BF, Patti GJ, Oh ST, Kim EH, Gillanders WE, Olson JA, Chheda MG, Weimholt C, Veis DJ, Raphael BJ, Fields RC, Pachynski RK, Chen F, Ding L.   +53 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Umpolung Character of Styrenes: Mechanism and Stereoselective Studies of α, β-Substituted Amino Acids Using Chiral Ir-Phosphine Complexes. [PDF]

J Comput Chem
Bhaskararao B, Antonio JJ, Kraka E.
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Gove Airport

, 1967
Gove airport, taken from the diary of L. H. Vale, lately attached to European Launcher Development Organisation (ELDO) - shows shed with cars and people waiting for plane.De La Rue, Kathy.Date ...

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