Results 211 to 220 of about 13,672,018 (258)

RSF1‐Dependent PAR Turnover Promotes 53BP1 Liquid Condensate Formation at DNA Damage Sites

Advanced Science, EarlyView.
At sites of DNA damage, RSF1 recruits PARG to accelerate PAR turnover, triggering a switch from PAR‐driven condensates to 53BP1 condensates. This condensate transition enables p53‐dependent gene transcription and coordinates the DNA damage response.
Yungyeong Heo, Yonghyeon Kim, Nangyeong Hwang, Gwanho Sung, Sujin Jo, Yeonhu Lee, Ho‐Chul Kang, Jae‐Ho Lee, Yong Won Choi, Hyeseong Cho, Sunwoo Min   +10 more
wiley   +1 more source

Acetatobis(l-arginine)copper(ii) acetate trihydrate: synthesis from l-argininium acetate, structural-electronic insights and <i>in vitro</i> antimicrobial activity. [PDF]

RSC Adv
Direm A, Samai S, Athmani H, Abdelbaky MSM, Parlak C, Abosede O, Garcia-Granda S, Ramasami P.   +7 more
europepmc   +1 more source

Compact 9dBEs Enable Efficient and Precise Genome Editing in Mammalian Cells and In Vivo

Advanced Science, EarlyView.
As a compact type II‐D system, the Cas9d‐based platform holds great potential for in vivo applications. Through rational engineering, its derived base editors (9dBEs) enable efficient disease modeling while facilitating single‐vector AAV delivery for in vivo genome editing. These miniature tools offer a robust strategy for basic research and biomedical
Qingquan Xiao, Zhijin Tian, Luqi Weng, Kun Xu, Dingyi Han, Zhaowei Wu, Junnan Li, Shangpu Li, Qijing Zhang, Xiaohui Zhao, Guoling Li, Yinghui Wei, Zhen Gu   +12 more
wiley   +1 more source

Effects of Stoichiometric Variations in L-Arginine-Cured Epoxy Resins. [PDF]

Polymers (Basel)
Walter M, Gibhardt D, Fiedler B.
europepmc   +1 more source

Diverging Liquid–Liquid Phase Separation Behavior of Different Recombinant Major Ampullate Spidroins

Advanced Science, EarlyView.
Fibers spun from the MaSp1‐derivative as well as MaSp1‐MaSp2‐mixtures provide a deeper insight into the assembly process of the spidroins and how hierarchical architectures of spider silk fibers could be achieved. ABSTRACT Spider silk fibers show exceptional mechanical properties, based on their underlying spider silk proteins (spidroins) as well as a ...
Tim Schiller, Cheryl Hayashi, Thomas R. Scheibel   +2 more
wiley   +1 more source

Gender-Related Differences in Cerebrovascular Reactivity to L-Arginine in Middle-Aged Type 1 Diabetes Patients. [PDF]

Int J Mol Sci
Kozera GM, Neubauer-Geryk J, Wolnik B, Szczyrba S, Bieniaszewski L.   +4 more
europepmc   +1 more source

Supramolecular Degraders: An Emerging Paradigm in Targeted Protein Degradation

Advanced Science, EarlyView.
Dynamic supramolecular assembly reshapes targeted protein degradation by coordinating modular degrader construction, delivery, functional integration, and intracellular assembly or activation across proteasomal, endosomal–lysosomal, and autophagy–lysosomal pathways.
Kongjun Liu, Xue Yuan, Yan Zhou, Rui Yuan, Shaocheng Xie, Yong Chen, Peiyi Wang, Jianmei Gao, Qihai Gong   +8 more
wiley   +1 more source

N^w-Hydroxy L-Arginine (NOHA): A Promising Biomarker of Response to Neoadjuvant Therapy in the Management of Triple Negative Breast Cancer. [PDF]

Cancer Rep (Hoboken)
Mohan S, Van Pelt DW, Saunders JG, DiPalazzo J, Monahan SE, Buchsbaum RJ, Frankenfeld CL, Bertaux BY, Miesfeldt S.   +8 more
europepmc   +1 more source

Nano Proton Scavengers Modulate Endosomal pH to Inhibit Microglial Activation and Enhance Stroke Recovery

Advanced Science, EarlyView.
Amphiphilic sulfonated chitosan nanoparticles buffer endo/lysosomal acidity in microglia by limiting V‐ATPase membrane recruitment and restoring endosomal homeostasis. Following systemic administration, they accumulate in the ischemic hemisphere partly through association with infiltrating immune cells, suppress TLR3/IRF3 and TLR4/NF‐κB signaling ...
Xuanlin Wang, Yujing Shi, Zehua Gao, Jing Wang, Changsheng Liu   +4 more
wiley   +1 more source

In vitro assessment of experimental bioactive tooth gel formulas containing L-arginine, ginger and eggshell for remineralization and anti-bacterial effect. [PDF]

Sci Rep
Saleh RS, El-Hashemy HA, Elgamily HM.
europepmc   +1 more source