Results 141 to 150 of about 14,921,642 (304)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Design and Optimization of High-Responsivity High-Speed Ge/Si Avalanche Photodiode in the C+L Band. [PDF]
Micromachines (Basel), 2022 Li C, Li X, Cai Y, Wang W, Yu M.
europepmc +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
University Concert Band, February 22, 2000
, 2016 Recorded during a live performance at Miller Auditorium, Western Michigan University, Kalamazoo, Michigan, February 22, 2000, 8:00 p.m., the 310th concert of the School of Music's 1999-2000 season.University Concert Band, John A.
Western Michigan University. Concert Band
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Development of an L-band resonator optimized for fast scan EPR imaging of the mouse head. [PDF]
Magn Reson Med, 2021 Samouilov A +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
University Symphonic Band, February 19, 1995
, 2016 Recorded during a live performance at Miller Auditorium, Western Michigan University, Kalamazoo, Michigan, February 19, 1995, 3:00 p.m., the 268th concert of the School of Music’s 1994-1995 season.Robert Spradling, conductor ; Trent Kynaston, alto ...
Western Michigan University. Symphonic Band
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Design of a Deployable Helix Antenna at L-Band for a 1-Unit CubeSat: From Theoretical Analysis to Flight Model Results. [PDF]
Sensors (Basel), 2022 Fernandez L +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source