Results 51 to 60 of about 797,532 (288)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

A High‐Sensitivity Circulating Nucleic Acid Sequencing Assay for Assessing Treatment Response to Alectinib in a Pediatric Patient With ALK‐Rearranged Non–Small Cell Lung Cancer

open access: yes
Pediatric Blood &Cancer, EarlyView.
Alberto D. Guerra   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Benchmarking the Retrieval of Biomass in Boreal Forests Using P-Band SAR Backscatter with Multi-Temporal C- and L-Band Observations

open access: yesRemote Sensing, 2019
The planned launch of a spaceborne P-band radar mission and the availability of C- and L-band data from several spaceborne missions suggest investigating the complementarity of C-, L-, and P-band backscatter with respect to the retrieval of forest above ...
Oliver Cartus   +3 more
doaj   +1 more source

Microwave L-band emission of freezing soil [PDF]

open access: yesIEEE Transactions on Geoscience and Remote Sensing, 2004
We report on field-measured microwave emission in a period of frost penetration into a grassland soil. The measurements were recorded with a high temporal resolution using an L-band radiometer mounted on a 7-m high tower. The observation period (December 2002 to March 2003) included two cycles of soil freezing and thawing with maximum frost depth of 25
Schwank, M.   +5 more
openaire   +4 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Snow Wetness Retrieved from L-Band Radiometry [PDF]

open access: yesRemote Sensing, 2018
The present study demonstrates the successful use of the high sensitivity of L-band brightness temperatures to snow liquid water in the retrieval of snow liquid water from multi-angular L-band brightness temperatures. The emission model employed was developed from parts of the “microwave emission model of layered snowpacks” (MEMLS), coupled with ...
Reza Naderpour, Mike Schwank
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The L-Band solar flux retrieval from the Soil Moisture and Ocean Salinity (SMOS) mission: Theoretical algorithm and its validation

open access: yesJournal of Space Weather and Space Climate
The Soil Moisture and Ocean Salinity (SMOS) satellite, launched in November 2009, is equipped with the Microwave Imaging Radiometer with Aperture Synthesis (MIRAS) payload, which collects high temporal resolution polarimetric data at 1.413 GHz (L-band ...
Crapolicchio Raffaele   +3 more
doaj   +1 more source

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