Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Penetration Analysis of SAR Signals in the C and L Bands for Wheat, Maize, and Grasslands
This paper assesses the potential of Synthetic Aperture Radar (SAR) in the C and L bands to penetrate into the canopy cover of wheat, maize and grasslands.
Mohammad El Hajj +3 more
doaj +1 more source
ATS-5 trilateration support [PDF]
The development of an L-band trilateration network capable of locating the ATS-5 satellite, determining the satellite's orbital elements, and predicting the satellite position was investigated.
Anderson, R. E., Brisken, A. F.
core +1 more source
"Ice cubes" in the center of the Milky Way - Water ice and hydrocarbons in the central parsec
The close environment of the central supermassive black hole of our Galaxy is studied thoroughly since decades in order to shed light on the behavior of the central regions of galaxies in general and of active galaxies in particular.
Eckart, Andreas +2 more
core +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Microwave remote sensing of soil moisture, volume 1 [PDF]
Multifrequency sensor data from NASA's C-130 aircraft were used to determine which of the all weather microwave sensors demonstrated the highest correlation to surface soil moisture over optimal bare soil conditions, and to develop and test techniques ...
Jones, C. L. +3 more
core +1 more source
Near-infrared proper motions and spectroscopy of infrared excess sources at the Galactic Center
There are a number of faint compact infrared excess sources in the central stellar cluster of the Milky Way. Their nature and origin is unclear. In addition to several isolated objects of this kind we find a small but dense cluster of co-moving sources ...
A. Eckart +106 more
core +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Detecting Arctic Icebergs in Sea Ice in L-Band SAR Images Using a Multiscale CFAR Algorithm
This study proposes a multiscale extension of the well-known constant false alarm rate (CFAR) outlier detection method for the detection of icebergs in L-band synthetic aperture radar (SAR) images. The proposed method offers the possibility to accurately
Laust Faerch +3 more
doaj +1 more source
Spin Hamiltonian Parameters for Cu(II)−Prion Peptide Complexes from L-Band Electron Paramagnetic Resonance Spectroscopy [PDF]
Cu(II) is an essential element for life but is also associated with numerous and serious medical conditions, particularly neurodegeneration. Structural modeling of crystallization-resistant biological Cu(II) species relies on detailed spectroscopic ...
Bennett, Brian, Kowalski, Jason M.
core +2 more sources

