Results 141 to 150 of about 3,604,485 (260)

Comparative effects of six rehabilitation therapies on lower limb function and gait function in stroke patients: a network meta-analysis of 33 RCTs. [PDF]

Front Neurol
Zhang S, Zhang H, Miao Z, Han J.
europepmc   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Thyroid Hormone in Women with Premature Ovarian Insufficiency: A Case-Control Study. [PDF]

Int J Womens Health
Zhang Y, Huang Y, Xu Y, Luo Z, Xu L, Ma L, Zhou J.   +6 more
europepmc   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Identification of a novel THRB mutation causing thyroid hormone resistance syndrome. [PDF]

Arch Endocrinol Metab
Yang J, Wang C, Quan L, Jiang S.
europepmc   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Renal Adverse Events Associated With Ibuprofen Treatment After Hip and Knee Arthroplasties-A Protocol for the Preplanned Substudy of the PERISAFE Trial. [PDF]

Acta Anaesthesiol Scand
Laursen CCW, Lund KN, Lunn TH, Hägi-Pedersen D, Therkelsen ASN, Steensbæk MT, Faugstad BI, Anjum S, Yilmaz M, Pedersen NA, Kappel A, Graungaard BK, Hollænder PB, Runge C, Lange KHW, Varnum C, Brorson S, Lindberg-Larsen M, Overgaard S, Olsen MH, Jakobsen JC, Mathiesen O.   +21 more
europepmc   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Evaluation of Clinical Characteristics and Lung Function Trajectories in Young COPD Patients Within the General Population. [PDF]

Int J Chron Obstruct Pulmon Dis
Nam JH, Rhee CK, Jo YS, Kim S, Kim YS, Kim SH, Kim KH, Choi JY.   +7 more
europepmc   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source