Results 131 to 140 of about 1,103,850 (332)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Isotope mass scaling and transport comparison between JET Deuterium and Tritium L-mode plasmas [PDF]
, 2023 T. Tala +27 more
openalex +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
L-mode-Edge Negative Triangularity Tokamak (NTT) Reactor
L-mode-Edge Negative Triangularity Tokamak (NTT) Reactorアジア太平洋物理学会連合、プラズマ物理部門の第２回年会において、Lモード端を持った負三角度トカマク核融合炉について口頭発表を行う。最近のDIII-Dの実験によって炉で必要となるHH=1.2, N=2.6のLモード端を持った高閉じ込め性能が得られたことから、熱・粒子制御性能に優れたLモード端を持った核融合炉概念が注目されている。特に、閉じ込め特性の改善HH=1.5によって、炉の主半径を9mから7mにコンパクト化できることを示す。 2nd Asia-Pacific Conference on Plasma Physics（AAPPS-DPP 2018）
openaire +1 more source
Reflection and Refraction of the L‐O Mode 5 kHz Saturn Narrowband Emission by the Magnetosheath [PDF]
, 2022 Siyuan Wu +7 more
openalex +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Successful prediction of tokamak transport in the L-mode regime
Nuclear FusionAbstract A long standing shortfall in the predicted L-mode edge energy transport by reduced quasi-linear models of gyrokinetic turbulent transport has been resolved. The improved model TGLF-SAT2 has higher fidelity to gyrokinetic simulations of the electron-scale contribution to the electron energy transport and the ion-scale flux ...
G.M. Staebler +11 more
openaire +3 more sources