Results 141 to 150 of about 1,103,850 (332)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Velocity profile shapes in Alcator C-Mod plasmas

Nuclear Fusion
Toroidal rotation velocity spatial profiles ( $r/a$ $ \lt $ 0.8) have been obtained from C-Mod over a wide range of operational conditions, including H-mode, I-mode, ICRF-heated L-mode and Ohmic L-mode (LOC and SOC), and in plasmas with ITBs, LH wave ...
J.E. Rice, N.M. Cao, A.E. Hubbard, J.W. Hughes   +3 more
doaj   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Interference-Resilient Communication With a 28 GHz Transceiver Utilizing OAM Waves

IEEE Journal of Microwaves
This article presents a custom-made SiGe-based transceiver at millimeter-wave frequencies capable of the generation and detection of radio waves with helical phase distribution called orbital angular momentum (OAM).
Atif H. Shah, Alireza Kiyaei, Subhan Zakir, Waleed Ahmad, Ebrahim M.Al Seragi, Ali Nikkhah, Mohammadreza F. Imani, Saeed Zeinolabedinzadeh   +7 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

3D‐Printed Macroporous Resin Anode in Microbial Fuel Cell‐Based Biosensors for Efficient Biodegradable Organic Carbon Monitoring

Advanced Sensor Research
In this study, a novel 3D‐printed glassy carbon gyroid anode is constructed using stereolithography, aiming to improve microbial fuel cell (MFC)‐based biosensor performance through a simple method that optimizes both the macroporous structure and ...
Anna Salvian, Junbin Huang, Daniel Farkas, John R. Varcoe, Claudio Avignone Rossa, Siddharth Gadkari   +5 more
doaj   +1 more source

Correlation of the L-mode density limit with edge collisionality

Nuclear Fusion
Abstract The ‘density limit’ is one of the fundamental bounds on tokamak operating space, and is commonly estimated via the empirical Greenwald scaling. This limit has garnered renewed interest in recent years as it has become clear that ITER and many tokamak pilot plant concepts must operate near or above the Greenwald limit to achieve ...
A.D. Maris, C. Rea, A. Pau, W. Hu, B. Xiao, R. Granetz, E. Marmar, the EUROfusion Tokamak Exploitation team, the Alcator C-Mod team, the ASDEX Upgrade team, the DIII-D Team, the EAST Team, and the TCV team   +12 more
openaire   +3 more sources

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Persea Americana L. (Avocado) Fruit Mesocarp intake in Experimental Diabetic Rats: Impacts and Implication of Mode of Consumption [PDF]

, 2021
Magnus Michael Chukwudike Anyakudo, Ifeoluwa Adekunle Adediji   +1 more
openalex   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source