Results 211 to 220 of about 297,845 (266)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Path integration in complex number space. [PDF]

Proc Natl Acad Sci U S A
Craddock P, Miossec Y, Bouchekioua Y.
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Chiroptics of In-Plane Excitons. [PDF]

J Phys Chem A
Sburlati S, Gustafson A, Kahr B.
europepmc   +1 more source

Effects of different dual-task trainings on gait and cortical activation during obstacle crossing in stroke patients: a randomized controlled trial. [PDF]

Front Physiol
Wan X, Zhu Z, Xu F, Li Q.
europepmc   +1 more source

Field-free control of magnetism and electronic states in ZGNR/h-BN heterojunctions <i>via</i> topological line defects. [PDF]

RSC Adv
Shan G, Chen W, Liu W.
europepmc   +1 more source

Diff-MomentFormer: Generative Diffusion-Augmented Transformer for End-to-End Joint Moment Estimation. [PDF]

Sensors (Basel)
Qiao C, Liu E, Ren J, He L.
europepmc   +1 more source

Reducing robotic upper-limb assessment time while maintaining precision: a time series foundation model approach. [PDF]

J Neuroeng Rehabil
Akbarifar F, Maghsoodi N, Dukelow SP, Scott SH, Mousavi P.   +4 more
europepmc   +1 more source

Computational Study of Linker Polarity Effects on Optical Electron Transfer in Imine- and Acylhydrazone-Linked Covalent Organic Frameworks Using Fragment Models. [PDF]

Molecules
Chen J, Qi D, Jiang J.
europepmc   +1 more source