Results 171 to 180 of about 44,068 (237)

ADAM17-dependent proteolysis of L-selectin promotes early clonal expansion of cytotoxic T cells. [PDF]

Sci Rep, 2019
Mohammed RN, Wehenkel SC, Galkina EV, Yates EK, Preece G, Newman A, Watson HA, Ohme J, Bridgeman JS, Durairaj RRP, Moon OR, Ladell K, Miners KL, Dolton G, Troeberg L, Kashiwagi M, Murphy G, Nagase H, Price DA, Matthews RJ, Knäuper V, Ager A.   +21 more
europepmc   +1 more source

Tumour‐Derived Extracellular Vesicles Containing dsRNA Induce Degradation of Ribosomal Protein mRNA in Platelets

Journal of Extracellular Vesicles, Volume 15, Issue 8, August 2026.
ABSTRACT Extracellular vesicles (EVs) mediate intercellular communication within the tumour microenvironment by carrying cargoes from paracrine parent cells. EVs have attracted great research interest for their ability to carry nucleic acids into recipient cells and modulate cellular functions.
Gaoge Sun, Yuhuan Tao, Zihan Liu, Kaixiang Zhang, Shuai Zuo, Shanwen Chen, Shufang Ning, Tianyi Zhang, Pengyuan Wang, Ying Zhang, Zhi John Lu, Hang Hubert Yin   +11 more
wiley   +1 more source

Nucleolin mediates the binding of cancer cells to L-selectin under conditions of lymphodynamic shear stress.

Am J Physiol Cell Physiol, 2020
Goldson TM, Turner KL, Huang Y, Carlson GE, Caggiano EG, Oberhauser AF, Fennewald SM, Burdick MM, Resto VA.   +8 more
europepmc   +1 more source

Shear‐Activated von Willebrand Factor Captures Extracellular Vesicles to Promote Platelet Activation and Metastasis

Journal of Extracellular Vesicles, Volume 15, Issue 8, August 2026.
Under shear flow, stretched vWF captures platelets and EVs, and TF‐positive EVs amplify platelet activation and aggregation. Although tumour cells do not bind vWF directly, the resulting microthrombi trap circulating tumour cells and promote metastatic progression.
Yuanyuan Wang, Xiaobo Liu, Pascal Nakielski, Katrin Nekipelov, Amanda Salviano‐Silva, Alper Topuz, Alexander T. Bauer, Julian Kött, Jannis Akrivakis, Santra Brenna, Tomasz Downar, Neus Feliu, Gerd Bendas, Berta Puig, Stefan W. Schneider, Dmitry A. Fedosov, Christian Gorzelanny   +16 more
wiley   +1 more source

Targeting CD162 for Life‐Threatening Cutaneous Chronic Graft‐Versus‐Host Disease: A Case Report

eJHaem, Volume 7, Issue 4, August 2026.
ABSTRACT Steroid‐refractory chronic cutaneous graft‐versus‐host disease (GVHD) causes substantial morbidity, prolonged hospitalization, and non‐relapse mortality after allogeneic hematopoietic cell transplantation. We report a young adult with multisystem chronic GVHD and recurrent life‐threatening inflammatory skin flares refractory to multiple ...
Alicia Lieberman, Ross McCauley, Maureen Ross, Philip McCarthy, Iming Cho, Simona Reed, Shih‐Yao Lin, Judy Chou, Shernan G. Holtan   +8 more
wiley   +1 more source

Dynamics in Pro‐Inflammatory Cytokines in Response to Hypoglossal Nerve Stimulation in Obstructive Sleep Apnea

Laryngoscope Investigative Otolaryngology, Volume 11, Issue 4, August 2026.
Obstructive sleep apnea (OSA) is associated with chronic low‐grade systemic inflammation. In cases of continuous positive airway pressure (PAP) failure, hypoglossal nerve stimulation (HNS) is a treatment option for OSA but its impact on systemic inflammation to date is unknown.
Ralph Pries, Yi Cai, Kirstin Plötze‐Martin, Sanja Jelic, Jonas Fleckner, Karl‐Ludwig Bruchhage, Armin Steffen   +6 more
wiley   +1 more source

Comparison of L-selectin blood level and gene polymorphism in tuberculosis patients with healthy individuals. [PDF]

J Clin Lab Anal, 2018
Eini P, Shirvani M, Hajilooi M, Esna-Ashari F.   +3 more
europepmc   +1 more source

Risk Factors for Cardiovascular Disease: Epidemiology, Screening, Prevention, and Therapeutic Interventions

MedComm, Volume 7, Issue 8, August 2026.
Cardiovascular disease arises from lifelong accumulation of traditional and emerging risk factors that converge on shared pathophysiological pathways, leading to diverse clinical outcomes, and can be mitigated through integrated screening, prevention, and precision therapies. ABSTRACT Cardiovascular diseases (CVDs) remain the leading cause of morbidity
Mowei Kong, Zaiyong Zheng, Min Huang, Shengyu Huang, Xingwei Zhao, Yang Yu, Chunxiang Zhang   +6 more
wiley   +1 more source

L-selectin mechanochemistry restricts neutrophil priming in vivo. [PDF]

Nat Commun, 2017
Liu Z, Yago T, Zhang N, Panicker SR, Wang Y, Yao L, Mehta-D'souza P, Xia L, Zhu C, McEver RP.   +9 more
europepmc   +1 more source

The Role of Inflammation and Immunity in Cardiovascular Disease: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 8, August 2026.
Inflammation in cardiovascular disease is a dynamic and context‐dependent network rather than a secondary response to injury. Mitochondrial danger signaling links metabolic stress to immune activation through TLR priming, NLRP3 inflammasome amplification, cGAS–STING signaling, and immunometabolic gating, providing a basis for more precise therapeutic ...
Jiaxiang Rong, Zhen Wang, Xiaoxiao Lin, Ziwen Lei, Qianqian Huang, Hang Liu, Fei Luan, Junbo Zou, Yajun Shi   +8 more
wiley   +1 more source