Results 81 to 90 of about 10,565,858 (290)
Bootstrapping the Small Sample Critical Values of the Rescaled Range Statistic [PDF]
Finite sample critical values of the rescaled range or R/S statistic may be obtained by bootstrapping. The empirical size and power performance of these critical values is good. Using the post blackened, moving block bootstrap helps to replicate the time
Marwan Izzeldin, Anthony Murphy
core
Hierarchical Gaussian Filtering of Sufficient Statistic Time Series for Active Inference
, 2020 Active inference relies on state-space models to describe the environments that agents sample with their actions. These actions lead to state changes intended to minimize future surprise.
Lilian Weber +3 more
core +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Health Technology Assessment, 2017 Background: The prognosis of early-onset pre-eclampsia (before 34 weeks’ gestation) is variable. Accurate prediction of complications is required to plan appropriate management in high-risk women.
Shakila Thangaratinam +16 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Simulated adjustment of the signed scoring rule root statistic
, 2015 We focus on adjustments of the signed scoring rule root statistic generalizing results for likelihood quantities. In particular, for a scalar parameter of interest, we investigate a bootstrap adjustment of the signed scoring rule root statistic.
L. Ventura +5 more
core
Two sides of the same coin: the F-statistic and the 5-vector method [PDF]
This work explores the relation between two data-analysis methods used in the search for continuous gravitational waves in LIGO-Virgo-KAGRA data: the F-statistic and the 5-vector method.
R De Rosa +23 more
core +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source