Results 91 to 100 of about 4,233 (285)

Palmitoylation‐Mediated Ubiquitination of SRPK1 Regulates Ferroptosis in High‐Fat‐Induced Erectile Dysfunction

open access: yesAdvanced Science, EarlyView.
Elevated exogenous palmitic acid promotes the S‐palmitoylation of SRPK1 in endothelial cells, a dynamic process governed by ZDHHC24 and APT1. This post‐translational modification strengthens the interaction between SRPK1 and the E3 ubiquitin ligase MIB1, thereby facilitating the proteasomal degradation of SRPK1.
Xiao‐Hui Tan   +11 more
wiley   +1 more source

Label‐Free Molecular Characterization of Protein Aggregates in Differentiated Astrocytes

open access: yesAdvanced Science, EarlyView.
Mid‐infrared photothermal microscopy enables label‐free structural, molecular, and functional imaging of protein aggregates in astrocyte cells. The processes of astrocytes differentiated on a nanomaterial interface are characterized by α‐helical signatures combined with enhanced interfacial thermal resistance properties, while the cell soma of non ...
Panagis D. Samolis   +9 more
wiley   +1 more source

Improving the utility of LA-ICP-MS for isotope ratio analyses of single particles with application to uranium oxide [PDF]

open access: yes, 2016
The determination of the isotopic composition of single uranium oxide particles, size 0.3-2 μm, for nuclear safeguards is current performed by either thermal ionisation mass spectrometry (TIMS) or Secondary Ion Mass Spectrometry (SIMS).
Grant Craig (5743340)
core  

Transparent Transfer‐Free Ultrasmall Multilayer Graphene Microelectrodes Enable High Quality Recordings in Brain Slices

open access: yesAdvanced Science, EarlyView.
A transfer‐free fabrication method enables multilayer graphene microelectrodes as small as 10 µm, eliminating reliability issues of manual graphene transfer. These electrodes record neural activity in brain slices with exceptional signal‐to‐noise ratios (up to 25–40 dB) while maintaining optical transparency for multimodal applications.
Nerea de Alvarez de Eulate   +7 more
wiley   +1 more source

Cassiterite U-Pb Dating with LA-MC-ICP-MS of the Laozhailing Cu-Sn Deposit, Yongzhou City, Hunan Province

open access: yesYankuang ceshi
Cassiterite is an important ore mineral in tin polymetallic deposits. Using cassiterite for dating tin polymetallic deposits has become one of the most direct methods to obtain the mineralization age of the deposits.
Yurong CUI   +7 more
doaj   +1 more source

Closed-system behaviour of the Re-Os isotope system recorded in primary and secondary platinum-group mineral assemblages : evidence from a mantle chromitite at Harold's Grave (Shetland ophiolite complex, Scotland) [PDF]

open access: yes, 2015
This study evaluates in detail the mineral chemistry, wholerock and mineral separate Os-isotope compositions of distinct platinumgroup mineral (PGM) assemblages in an isolated chromitite pod at Harold's Grave which occurs in mantle tectonite in the ...
Badanina, Inna Yu.   +4 more
core   +1 more source

Biomimetic Nanomedicine for Senescence‐Modulated Immune Activation Enhances Immunotherapy Efficacy in Hepatocellular Carcinoma

open access: yesAdvanced Science, EarlyView.
A multifunctional mPDZM nanoplatform is developed in this study. mPDZM integrates chemotherapy‐induced senescence, selective senolysis, and STING‐mediated immune activation. mPDZM effectively clears senescent tumor cells, remodels the tumor immune microenvironment, and enhances antitumor T‐cell responses.
Shiji Fang   +17 more
wiley   +1 more source

Petrogenesis Research of Basic Rock in the Hongliugou Area of the Altun Orogen Based on Baddeleyite Chronology and Whole-Rock Geochemical Analyses

open access: yesYankuang ceshi
Previous studies suggest that the Alton Block may have participated in the breakup of the Rodinia supercontinent, however, there have been no prior reports of intraplate basic-ultrabasic rock bodies in the region.
Yanguang LI   +3 more
doaj   +1 more source

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