Results 11 to 20 of about 9,862 (201)
Angewandte Chemie, EarlyView.Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma +5 more
wiley +2 more sources
Angewandte Chemie, EarlyView.Lenacapavir, the first‐in‐class drug targeting HIV‐1 capsid, is a breakthrough drug in HIV‐1 treatment and prophylaxis. However, a single M66I mutation confers complete viral resistance to lenacapavir. We report herein the design and synthesis of innovative R2 analogs demonstrating low nM potency against HIV‐1 M66I and excellent pharmacokinetics in ...
Nicolas Jamey +13 more
wiley +2 more sources
Traducir la pampa: sobre las versiones de L’Homme de la pampa, de Jules Supervielle
Mutatis Mutandis. Revista Latinoamericana de Traducción, 2022 Cuando el escritor francés —de origen uruguayo— Jules Supervielle (1884-1960) publica en 1923 su primera novela, L'Homme de la pampa, su amigo y mentor Valéry Larbaud la llama la entrada de la República Oriental a la literatura francesa. De tema marcadamente gaucho, al menos en su primera parte, la novela va a ser pronto traducida al castellano ...
openaire +3 more sources
Backbone Steric Constraints Underlie High Passive Membrane Permeability of N‐Alkyl Peptides
Angewandte Chemie, EarlyView.Beyond amide hydrogen removal, steric constraints encoded in N/Cα‐dually substituted backbones are uncovered as a key determinant of passive membrane permeability in N‐alkyl peptides. These constraints restrict conformational freedom and sterically limit backbone hydration during membrane permeation.
Ayumi Inayoshi +8 more
wiley +2 more sources
Octante, 2019 El artículo resume los objetivos y los avances del proyecto de tesis para la Licenciatura en Historia del Arte de la Facultad de Bellas Artes (FBA) de la Universidad Nacional de La Plata (UNLP), titulado Experiencia y representación pampeana. Aportes para la comprensión del género paisaje a partir del estudio de la obra de Eduardo Sívori.
openaire +3 more sources
Geophysical Monograph Series, Page 169-190., 2021 Exploring the links between Large Igneous Provinces and dramatic environmental impact
An emerging consensus suggests that Large Igneous Provinces (LIPs) and Silicic LIPs (SLIPs) are a significant driver of dramatic global environmental and biological changes, including mass extinctions.
Nasrrddine Youbi +9 more
wiley +1 more source
Desarrollo Económico, 1996 tiempo) la historia rural pampeana ha sido relativamente pacifica. Esta ausencia de conflicto es, para muchos, el 16gico correlato de una estructura agraria particular que se fue conformando de acuerdo con condiciones hist6ricas especlficas: en tanto "regi6n abierta" con moltiples ventajas comparativas, la regi6n pampeana vivi6 la transici6n al ...
Juan Manuel R. Palacio, Waldo Ansaldi
openaire +1 more source
Advanced Science, EarlyView.Non‐canonical amino acids (ncAAs) enhance peptide therapeutics but remain difficult to model computationally. SinCAA, a similarity‐enhanced pretraining framework, jointly optimizes contrastive learning guided by a novel conformational similarity metric with masked node reconstruction, capturing both functional relationships and chemical identity of ...
Chencheng Xu +8 more
wiley +1 more source
Advanced Science, EarlyView.Modular zinc finger (ZF) metalloproteins function as programmable biomolecular scaffolds that modulate pathogenic amyloid assembly. Through direct protein–protein interactions, ZF arrays alter amyloid phase behavior and redirect β‐sheet fibrillization toward nontoxic aggregates.
Seongmin Park +16 more
wiley +1 more source
Autonomous AI‐Driven Design for Skin Product Formulations
Advanced Intelligent Discovery, EarlyView.This review presents a comprehensive closed‐loop framework for autonomous skin product formulation design. By integrating artificial intelligence‐driven experiment selection with automated multi‐tiered assays, the approach shifts development from trial‐and‐error to intelligent optimisation.
Yu Zhang +5 more
wiley +1 more source