Results 101 to 110 of about 82,714 (300)

Direct writing of optical microresonators in a lab-on-a-chip for label-free biosensing.

Lab on a Chip, 2019
Whispering gallery mode (WGM) resonators are promising optical structures for microfluidic label-free biosensors mainly due to their high sensitivity, but from a practical point of view they present numerous constraints that make their use in real ...
L. Kelemen, E. Lepera, B. Horváth, P. Ormos, R. Osellame, R. Vázquez   +5 more
semanticscholar   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Fabrication of a Monolithic Lab-on-a-Chip Platform with Integrated Hydrogel Waveguides for Chemical Sensing

Italian National Conference on Sensors, 2019
Hydrogel waveguides have found increased use for variety of applications where biocompatibility and flexibility are important. In this work, we demonstrate the use of polyethylene glycol diacrylate (PEGDA) waveguides to realize a monolithic lab-on-a-chip
M. L. Torres‐Mapa, Manmeet Singh, O. Simón, J. Mapa, M. Machida, A. Günther, B. Roth, D. Heinemann, M. Terakawa, A. Heisterkamp   +9 more
semanticscholar   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Acoustically Actuated Flow in Microrobots Powered by Axisymmetric Resonant Bubbles

Advanced Intelligent Systems
Bubble‐driven microsystems inspired by the therapeutic use of microbubbles under clinical ultrasound actuation offer innovative remote manipulation in biological settings.
Sumit Mohanty, Yu-Hsiang Lin, Aniruddha Paul, Martin R. P. van den Broek, Tim Segers, Sarthak Misra   +5 more
doaj   +1 more source

Future of lab on a chip [PDF]

Biomedical Engineering Letters, 2012
Biological and medical applications of lab a on a chip is a timely topic that is active area of research worldwide. Biomedical Engineering Letters is well positioned to contribute to reporting important results in this area. The field is continually evolving as lab on chip technologies and associated fabrication methods mature and the focus of research
openaire   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Passive Heat Stimuli as a Systemic Training in Elite Endurance Athletes: A New Strategy to Promote Greater Metabolic Flexibility

Journal of Functional Morphology and Kinesiology
Objectives: The ability to efficiently regulate body temperature is crucial during endurance activities such as trail running, especially during competitive events in hot conditions.
Sergi Cinca-Morros, Martin Burtscher, Fernando Benito-Lopez, Jesús Álvarez-Herms   +3 more
doaj   +1 more source