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IEE Colloquium on Microsensors in Medicine, 1997
Using the example of open-tubular liquid chromatography, the authors demonstrate improved performance, cheap and simple production and miniaturisation through microengineering. Improved performance can result from efficient heat transfer (capillary electrophoresis and PCR), reduced diffusion path lengths (chromatography and coupled chemical reactions ...
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Using the example of open-tubular liquid chromatography, the authors demonstrate improved performance, cheap and simple production and miniaturisation through microengineering. Improved performance can result from efficient heat transfer (capillary electrophoresis and PCR), reduced diffusion path lengths (chromatography and coupled chemical reactions ...
openaire +1 more source
Lab-on-a-chip for drug development
Advanced Drug Delivery Reviews, 2003Significant advances have been made in the development of micro-scale technologies for biomedical and drug discovery applications. The first generation of microfluidics-based analytical devices have been designed and are already functional. Microfluidic devices offer unique advantages in sample handling, reagent mixing, separation, and detection.
Bernhard H, Weigl +2 more
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From lab-on-a-chip to lab-in-a-cell
SPIE Proceedings, 2005There are many efforts today trying to mimic the properties of single cells in order to design chips that are as efficient as cells. However, cells are nature"s nanotechnology engineering at the scale of atoms and molecules. Therefore, it might be better to vision a microchip that utilizes a single cell as experimentation platform.
Andersson, Helene, van den Berg, Albert
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Lab on a Chip for Live-Cell Manipulation
IEEE Design & Test of Computers, 2007Precisely manipulating and sorting live cells on a lab on a chip is still a major challenge. This article shows how to use dielectrophoresis for cell sorting. The authors also describe a prototype CMOS chip with a sensor-actuator array, row-column addressing logic and readout circuitry.
G. Medoro +4 more
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Lab-on-a-Chip Multiplex Assays
2016Lab-on-a-chip multiplex assays allow a rapid identification of multiple parameters in an automated manner. Here we describe a lab-based preparation followed by a rapid and fully automated DNA microarray hybridization and readout in less than 10 min using the Fraunhofer in vitro diagnostics (ivD) platform to enable rapid identification of bacterial ...
Harald, Peter +2 more
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Scientific American, 2007
Squeezing a chemistry lab down to fingernail size could provide instant medical tests at home and on the ...
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Squeezing a chemistry lab down to fingernail size could provide instant medical tests at home and on the ...
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Lab-on-a-chip: applications in proteomics
Current Opinion in Chemical Biology, 2002Recent advances in chip-based separation of proteins provide methods that are faster and more convenient than conventional gel electrophoresis. Rapid and automated protein sizing on a chip is at the commercial stage and first attempts have been made to perform two-dimensional separation on a chip.
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Computer-aided Design Techniques for Flow-based Microfluidic Lab-on-a-chip Systems
ACM Computing Surveys, 2022Xing Huang, Tsung-Yi Ho, Wenzhong Guo
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