Results 1 to 10 of about 59,136 (254)

Engineered Vasculature for Organ-on-a-Chip Systems

Engineering, 2022
Organ-on-a-chip technology, a promising three-dimensional (3D) dynamic culture method, ensures accurate and efficient cell culture and has great potential for replacing animal models in preclinical testing. The circulatory system, the most abundant organ
Abdellah Aazmi, Hongzhao Zhou, Yuting Li, Mengfei Yu, Xiaobin Xu, Yutong Wu, Liang Ma, Bin Zhang, Huayong Yang   +8 more
doaj   +3 more sources

Organ-on-a-Chip and Lab-on-a-Chip Technologies in Cardiac Tissue Engineering [PDF]

Biomimetics
Microfluidic technologies have ushered in a new era in cardiac tissue engineering, providing more predictive in vitro models compared to two-dimensional culture studies. This review examines Organ-on-a-Chip (OoC) and Lab-on-a-Chip (LoC) platforms, with a
Daniele Marazzi, Federica Trovalusci, Paolo Di Nardo, Felicia Carotenuto   +3 more
doaj   +2 more sources

Organ-on-a-chip and the kidney

Kidney Research and Clinical Practice, 2015
Traditional approaches to pathophysiology are advancing but still have many limitations that arise from real biologic systems and their associated physiological phenomena being too complicated.
Sejoong Kim, Shuichi Takayama
doaj   +4 more sources

A Comprehensive Review of Organ-on-a-Chip Technology and Its Applications

Biosensors
Organ-on-a-chip (OOC) is an emerging technology that simulates an artificial organ within a microfluidic cell culture chip. Current cell biology research focuses on in vitro cell cultures due to various limitations of in vivo testing.
Negar Farhang Doost, Soumya K. Srivastava   +1 more
doaj   +3 more sources

Breakthroughs and Applications of Organ-on-a-Chip Technology

Cells, 2022
Organ-on-a-chip (OOAC) is an emerging technology based on microfluid platforms and in vitro cell culture that has a promising future in the healthcare industry. The numerous advantages of OOAC over conventional systems make it highly popular.
Tej Pandita, Tej Pandita, Shreeram Joglekar   +2 more
exaly   +4 more sources

Microfluidic Organ/Body-on-a-Chip Devices at the Convergence of Biology and Microengineering

Sensors, 2015
Recent advances in biomedical technologies are mostly related to the convergence of biology with microengineering. For instance, microfluidic devices are now commonly found in most research centers, clinics and hospitals, contributing to more accurate ...
Ana Rubina Perestrelo, Ana C. P. Águas, Alberto Rainer, Giancarlo Forte   +3 more
doaj   +3 more sources

Organ-on-a-Chip Applications in Microfluidic Platforms. [PDF]

Micromachines (Basel)
Microfluidic technology plays a crucial role in organ-on-a-chip (OoC) systems by replicating human physiological processes and disease states, significantly advancing biomedical research and drug discovery. This article reviews the design and fabrication processes of microfluidic devices.
An L, Liu Y, Liu Y.
europepmc   +4 more sources

Organ-on-a-chip toxicology. [PDF]

Innovation (Camb)
Yang S, Zhang T, Ge Y, Niu Y, Chen M, Yin L, Pu Y, Chen Z, Gu Z, Liang G.   +9 more
europepmc   +2 more sources

Organ-on-a-Chip

RSC advances, 2020
Limitations of the current tools used in the drug development process, cell cultures, and animal models have highlighted the need for a new powerful tool that can emulate the human physiology in vitro. Advances in the field of microfluidics have made the realization of this tool closer than ever.
Ilka, Maschmeyer, Sofia, Kakava
  +5 more sources

Breaking the Third Wall: Implementing 3D-Printing Techniques to Expand the Complexity and Abilities of Multi-Organ-on-a-Chip Devices

Micromachines, 2021
The understanding that systemic context and tissue crosstalk are essential keys for bridging the gap between in vitro models and in vivo conditions led to a growing effort in the last decade to develop advanced multi-organ-on-a-chip devices.
Yoel Goldstein, Sarah Spitz, Keren Turjeman, Florian Selinger, Yechezkel Barenholz, Peter Ertl, Ofra Benny, Danny Bavli   +7 more
doaj   +1 more source