Recent advances in vascularized tumor-on-a-chip [PDF]
Frontiers in Oncology, 2023 The vasculature plays a critical role in cancer progression and metastasis, representing a pivotal aspect in the creation of cancer models. In recent years, the emergence of organ-on-a-chip technology has proven to be a robust tool, capable of ...
Christina Bao Xian Huang +3 more
doaj +5 more sources
Hybrid-integrated devices for mimicking malignant brain tumors (“tumor-on-a-chip”) for in vitro development of targeted drug delivery and personalized therapy approaches [PDF]
Frontiers in MedicineAcute and requiring attention problem of oncotheranostics is a necessity for the urgent development of operative and precise diagnostics methods, followed by efficient therapy, to significantly reduce disability and mortality of citizens.
Tatiana M. Zimina +6 more
doaj +3 more sources
Diversity Models and Applications of 3D Breast Tumor-on-a-Chip [PDF]
Micromachines, 2021 Breast disease is one of the critical diseases that plague females, as is known, breast cancer has high mortality, despite significant pathophysiological progress during the past few years.
Kena Song +5 more
doaj +4 more sources
Tumor-on-a-chip: Perfusable vascular incorporation brings new approach to tumor metastasis research and drug development [PDF]
Frontiers in Bioengineering and Biotechnology, 2022 The extracellular matrix interacts with cancer cells and is a key factor in the development of cancer. Traditional two-dimensional models cannot mimic the natural in situ environment of cancer tissues, whereas three-dimensional (3D) models such as ...
Ruixin Wang +3 more
doaj +4 more sources
Microfluidic Tumor-on-a-Chip Model to Study Tumor Metabolic Vulnerability [PDF]
International Journal of Molecular Sciences, 2020 Tumor-specific metabolic adaptations offer an interesting therapeutic opportunity to selectively destroy cancer cells. However, solid tumors also present gradients of nutrients and waste products across the tumor mass, forcing tumor cells to adapt their ...
Vijayasaradhi Setaluri +2 more
exaly +3 more sources
Metabolic Switching of Tumor Cells under Hypoxic Conditions in a Tumor-on-a-chip Model [PDF]
Micromachines, 2020 Hypoxia switches the metabolism of tumor cells and induces drug resistance. Currently, no therapeutic exists that effectively and specifically targets hypoxic cells in tumors.
Valentina Palacio-Castañeda +4 more
doaj +4 more sources
Organ-Tumor-on-a-Chip for Chemosensitivity Assay: A Critical Review
Micromachines, 2016 With a mortality rate over 580,000 per year, cancer is still one of the leading causes of death worldwide. However, the emerging field of microfluidics can potentially shed light on this puzzling disease.
Navid Kashaninejad +7 more
doaj +4 more sources
A fully 3D-printed versatile tumor-on-a-chip allows multi-drug screening and correlation with clinical outcomes for personalized medicine. [PDF]
Commun Biol, 2023 Optimal clinical outcomes in cancer treatments could be achieved through the development of reliable, precise ex vivo tumor models that function as drug screening platforms for patient-targeted therapies. Microfluidic tumor-on-chip technology is emerging
Steinberg E +8 more
europepmc +2 more sources
Reaching the Tumor: Mobility of Polymeric Micelles Inside an In Vitro Tumor-on-a-Chip Model with Dual ECM. [PDF]
ACS Appl Mater Interfaces, 2023 Degradable polymeric micelles are promising drug delivery systems due to their hydrophobic core and responsive design. When applying micellar nanocarriers for tumor delivery, one of the bottlenecks encountered in vivo is the tumor tissue barrier ...
Olea AR +8 more
europepmc +2 more sources
A lung tumor-on-a-chip model recapitulates the effect of hypoxia on radiotherapy response and FDG-PET imaging. [PDF]
Lab ChipMost solid tumors contain regions of hypoxia that pose a significant challenge to the efficacy of radiation therapy. This study introduces a novel 3D lung tumor-on-a-chip (ToC) model designed to replicate the hypoxic tumor microenvironment in vitro while
Nasiri R +8 more
europepmc +3 more sources