Recent advances in vascularized tumor-on-a-chip [PDF]
Frontiers in Oncology, 2023 The vasculature plays a critical role in cancer progression and metastasis, representing a pivotal aspect in the creation of cancer models. In recent years, the emergence of organ-on-a-chip technology has proven to be a robust tool, capable of ...
Christina Bao Xian Huang +3 more
doaj +3 more sources
3D-Printed Tumor-on-a-Chip Model for Investigating the Effect of Matrix Stiffness on Glioblastoma Tumor Invasion [PDF]
Biomimetics, 2023 Glioblastoma multiform (GBM) tumor progression has been recognized to be correlated with extracellular matrix (ECM) stiffness. Dynamic variation of tumor ECM is primarily regulated by a family of enzymes which induce remodeling and degradation.
Meitham Amereh +5 more
doaj +3 more sources
Hybrid-integrated devices for mimicking malignant brain tumors (“tumor-on-a-chip”) for in vitro development of targeted drug delivery and personalized therapy approaches [PDF]
Frontiers in MedicineAcute and requiring attention problem of oncotheranostics is a necessity for the urgent development of operative and precise diagnostics methods, followed by efficient therapy, to significantly reduce disability and mortality of citizens.
Tatiana M. Zimina +6 more
doaj +3 more sources
Diversity Models and Applications of 3D Breast Tumor-on-a-Chip [PDF]
Micromachines, 2021 Breast disease is one of the critical diseases that plague females, as is known, breast cancer has high mortality, despite significant pathophysiological progress during the past few years.
Kena Song +5 more
doaj +4 more sources
Metabolic Switching of Tumor Cells under Hypoxic Conditions in a Tumor-on-a-chip Model [PDF]
Micromachines, 2020 Hypoxia switches the metabolism of tumor cells and induces drug resistance. Currently, no therapeutic exists that effectively and specifically targets hypoxic cells in tumors.
Valentina Palacio-Castañeda +4 more
doaj +4 more sources
A fully 3D-printed versatile tumor-on-a-chip allows multi-drug screening and correlation with clinical outcomes for personalized medicine. [PDF]
Commun Biol, 2023 Optimal clinical outcomes in cancer treatments could be achieved through the development of reliable, precise ex vivo tumor models that function as drug screening platforms for patient-targeted therapies. Microfluidic tumor-on-chip technology is emerging
Steinberg E +8 more
europepmc +2 more sources
Tumor-on-a-chip: from bioinspired design to biomedical application. [PDF]
Microsyst Nanoeng, 2021 Cancer is one of the leading causes of human death, despite enormous efforts to explore cancer biology and develop anticancer therapies. The main challenges in cancer research are establishing an efficient tumor microenvironment in vitro and exploring ...
Liu X +9 more
europepmc +2 more sources
A lung tumor-on-a-chip model recapitulates the effect of hypoxia on radiotherapy response and FDG-PET imaging. [PDF]
Lab ChipMost solid tumors contain regions of hypoxia that pose a significant challenge to the efficacy of radiation therapy. This study introduces a novel 3D lung tumor-on-a-chip (ToC) model designed to replicate the hypoxic tumor microenvironment in vitro while
Nasiri R +8 more
europepmc +2 more sources
Tumor-on-a-chip: Perfusable vascular incorporation brings new approach to tumor metastasis research and drug development [PDF]
Frontiers in Bioengineering and Biotechnology, 2022 The extracellular matrix interacts with cancer cells and is a key factor in the development of cancer. Traditional two-dimensional models cannot mimic the natural in situ environment of cancer tissues, whereas three-dimensional (3D) models such as ...
Ruixin Wang +3 more
doaj +2 more sources
Extracellular matrix regulation of cell spheroid invasion in a 3D bioprinted solid tumor-on-a-chip. [PDF]
Acta BiomaterTumor organoids and tumors-on-chips can be built by placing patient-derived cells within an extracellular matrix (ECM) for personalized medicine. The ECM influences the tumor response, and understanding the ECM-tumor relationship is important before ...
Dogan E +5 more
europepmc +2 more sources