Results 1 to 10 of about 91,694,512 (315)

Recent advances in vascularized tumor-on-a-chip [PDF]

Frontiers in Oncology, 2023
The vasculature plays a critical role in cancer progression and metastasis, representing a pivotal aspect in the creation of cancer models. In recent years, the emergence of organ-on-a-chip technology has proven to be a robust tool, capable of ...
Christina Bao Xian Huang, Ting-Yuan Tu, Ting-Yuan Tu, Ting-Yuan Tu   +3 more
doaj   +5 more sources

Diversity Models and Applications of 3D Breast Tumor-on-a-Chip [PDF]

Micromachines, 2021
Breast disease is one of the critical diseases that plague females, as is known, breast cancer has high mortality, despite significant pathophysiological progress during the past few years.
Kena Song, Xiangyang Zu, Zhe Du, Zhigang Hu, Jingjing Wang, Jinghua Li   +5 more
doaj   +6 more sources

Organ-Tumor-on-a-Chip for Chemosensitivity Assay: A Critical Review [PDF]

Micromachines, 2016
With a mortality rate over 580,000 per year, cancer is still one of the leading causes of death worldwide. However, the emerging field of microfluidics can potentially shed light on this puzzling disease.
Navid Kashaninejad, Mohammad Reza Nikmaneshi, Hajar Moghadas, Amir Kiyoumarsi Oskouei, Milad Rismanian, Maryam Barisam, Mohammad Said Saidi, Bahar Firoozabadi   +7 more
doaj   +7 more sources

Tumor-on-a-chip platform to interrogate the role of macrophages in tumor progression [PDF]

Integrative Biology (United Kingdom), 2020
Abstract Tumor-infiltrating leukocytes, in particular macrophages, play an important role in tumor behavior and clinical outcome. The spectrum of macrophage subtypes ranges from antitumor “M1”-type to protumor “M2”-type macrophages.
Ye Bi, Venktesh S Shirure, Ruiyang Liu
exaly   +8 more sources

An Advanced 3D Model of Vascularized Epithelial Ovarian Cancer in a Tumor-on-a-Chip System Based on Multi-Cell Culture [PDF]

Sensors
Epithelial ovarian cancer (EOC) is a highly lethal malignancy characterized by significant heterogeneity and poor prognosis due to late-stage diagnosis and chemotherapy resistance.
Magdalena Flont, Agnieszka Żuchowska, Oliwia Tadko, Joanna Konopka, Paulina Musolf, Agnieszka Gnyszka, Patrycja Baranowska, Elżbieta Jastrzębska   +7 more
doaj   +3 more sources

Metabolic Switching of Tumor Cells under Hypoxic Conditions in a Tumor-on-a-chip Model [PDF]

Micromachines, 2020
Hypoxia switches the metabolism of tumor cells and induces drug resistance. Currently, no therapeutic exists that effectively and specifically targets hypoxic cells in tumors.
Valentina Palacio-Castañeda, Lucas Kooijman, Bastien Venzac, Wouter P.R. Verdurmen, Séverine Le Gac   +4 more
doaj   +4 more sources

A vascularized tumors-on-a-chip model for studying tumor-angiogenesis interplay, heterogeneity and drug responses

Materials Today Bio
Current tumor models struggle to replicate the complexity of the tumor microenvironment, particularly endothelial sprouting and vascular-tumor interactions.
Suyeon Shin, Yurim Choi, WonJun Jang, Batjargal Ulziituya, Giheon Ha, Raehui Kang, Soojin Park, Minseok Kim, Yu Shrike Zhang, Han-Jun Kim, Junmin Lee   +10 more
doaj   +3 more sources

Multimodal Multiorgan‐on‐a‐Chip Platform for Probing Liver‐Tumor Interactions and Advancing Prodrug Screening

Advanced Science
To advance the development of microphysiological systems with enhanced metabolic fidelity, there is a critical need to recapitulate native three‐dimensional multicellular architecture, enabling non‐invasive, multi‐parameter measurements. Here, we present
Dan Wang, Yisong Huang, Weijian Zhao, Tian Chen, Siyu Bai, Denghui Guo, Mengying Wang, Yaoyao Zhao, Liang Zhao, Guangsheng Guo, Xiayan Wang   +10 more
doaj   +2 more sources

Dissecting Effects of Anti-cancer Drugs and Cancer-Associated Fibroblasts by On-Chip Reconstitution of Immunocompetent Tumor Microenvironments

Cell Reports, 2018
Summary: A major challenge in cancer research is the complexity of the tumor microenvironment, which includes the host immunological setting. Inspired by the emerging technology of organ-on-chip, we achieved 3D co-cultures in microfluidic devices ...
Marie Nguyen, Adele De Ninno, Arianna Mencattini, Fanny Mermet-Meillon, Giulia Fornabaio, Sophia S. Evans, Mélissande Cossutta, Yasmine Khira, Weijing Han, Philémon Sirven, Floriane Pelon, Davide Di Giuseppe, Francesca Romana Bertani, Annamaria Gerardino, Ayako Yamada, Stéphanie Descroix, Vassili Soumelis, Fatima Mechta-Grigoriou, Gérard Zalcman, Jacques Camonis, Eugenio Martinelli, Luca Businaro, Maria Carla Parrini   +22 more
doaj   +3 more sources

Glioma-on-a-Chip Models

Micromachines, 2021
Glioma, as an aggressive type of cancer, accounts for virtually 80% of malignant brain tumors. Despite advances in therapeutic approaches, the long-term survival of glioma patients is poor (it is usually fatal within 12–14 months).
Merve Ustun, Sajjad Rahmani Dabbagh, Irem Sultan Ilci, Tugba Bagci-Onder, Savas Tasoglu   +4 more
doaj   +1 more source