Results 41 to 50 of about 138,643 (133)

Three-Dimensional In Vitro Lymphangiogenesis Model in Tumor Microenvironment

Frontiers in Bioengineering and Biotechnology, 2021
Lymphangiogenesis is a stage of new lymphatic vessel formation in development and pathology, such as inflammation and tumor metastasis. Physiologically relevant models of lymphatic vessels have been in demand because studies on lymphatic vessels are ...
Youngkyu Cho, Youngkyu Cho, Kyuhwan Na, Yesl Jun, Yesl Jun, Jihee Won, Ji Hun Yang, Ji Hun Yang, Seok Chung, Seok Chung   +9 more
doaj   +1 more source

An in vitro model of cancer invasion with heterogeneous ECM created with droplet microfluidics

Frontiers in Bioengineering and Biotechnology, 2023
Metastasis is a multi-step process that is critically affected by cues from the tumor micro-environment (TME), such as from the extracellular matrix (ECM). The role of the ECM in the onset of metastasis, invasion, is not yet fully understood.
Mohammad Jouybar, Mohammad Jouybar, Jelle J. F. Sleeboom, Jelle J. F. Sleeboom, Jelle J. F. Sleeboom, Elnaz Vaezzadeh, Cecilia M. Sahlgren, Cecilia M. Sahlgren, Cecilia M. Sahlgren, Jaap M. J. den Toonder, Jaap M. J. den Toonder   +10 more
doaj   +1 more source

Metastasis in context: modeling the tumor microenvironment with cancer-on-a-chip approaches

Disease Models & Mechanisms, 2018
Most cancer deaths are not caused by the primary tumor, but by secondary tumors formed through metastasis, a complex and poorly understood process.
Jelle J. F. Sleeboom, Hossein Eslami Amirabadi, Poornima Nair, Cecilia M. Sahlgren, Jaap M. J. den Toonder   +4 more
doaj   +1 more source

Therapeutic targeting of tumor spheroids in a 3D microphysiological renal cell carcinoma-on-a-chip system

Neoplasia, 2023
Metastatic renal cell carcinoma (RCC) remains an incurable disease for most patients highlighting an urgent need for new treatments. However, the preclinical investigation of new therapies is limited by traditional two-dimensional (2D) cultures which do ...
Christopher P. Miller, Megan Fung, Carla A. Jaeger-Ruckstuhl, Yuexin Xu, E. Warren, Shreeram Akilesh, S. Tykodi   +6 more
semanticscholar   +1 more source

3D cancer models: One step closer to in vitro human studies

Frontiers in Immunology, 2023
Cancer immunotherapy is the great breakthrough in cancer treatment as it displayed prolonged progression-free survival over conventional therapies, yet, to date, in only a minority of patients.
Nicoletta Manduca, Ester Maccafeo, Ruggero De Maria, Ruggero De Maria, Antonella Sistigu, Martina Musella   +5 more
doaj   +1 more source

Organ-on-a-Chip Platforms for Drug Screening and Delivery in Tumor Cells: A Systematic Review

Cancers, 2022
Simple Summary Cancer is one of the diseases with a high mortality rate worldwide. Of the current strategies to study new diagnostic and treating tools, organs-on-chip are quite promising regarding the achievement of more personalized medicine.
I. Gonçalves, V. Carvalho, Raquel O. Rodrigues, D. Pinho, S. Teixeira, A. Moita, Takeshi Hori, H. Kaji, Rui A. Lima, G. Minas   +9 more
semanticscholar   +1 more source

Engineering Three-Dimensional Tumor Models to Study Glioma Cancer Stem Cells and Tumor Microenvironment

Frontiers in Cellular Neuroscience, 2020
Glioblastoma (GBM) is the most common and devastating primary brain tumor, leading to a uniform fatality after diagnosis. A major difficulty in eradicating GBM is the presence of microscopic residual infiltrating disease remaining after multimodality ...
Henry Ruiz-Garcia, Henry Ruiz-Garcia, Keila Alvarado-Estrada, Paula Schiapparelli, Alfredo Quinones-Hinojosa, Daniel M. Trifiletti, Daniel M. Trifiletti   +6 more
doaj   +1 more source

In vitro models of breast cancer bone metastasis: analyzing drug resistance through the lens of the microenvironment

Frontiers in Oncology, 2023
Even though breast cancers usually have a good outcome compared to other tumors, the cancer can progress and create metastases in different parts of the organism, the bone being a predilection locus.
Anaïs Lamouline, Anaïs Lamouline, Anaïs Lamouline, Simone Bersini, Simone Bersini, Simone Bersini, Matteo Moretti, Matteo Moretti, Matteo Moretti, Matteo Moretti   +9 more
doaj   +1 more source

Tumor‐On‐A‐Chip Model Incorporating Human‐Based Hydrogels for Easy Assessment of Metastatic Tumor Inter‐Heterogeneity

Advanced Functional Materials
The coordinated migration of invasive tumor cells is a complex and dynamic mechanism driven by diverse cellular and molecular events. Unfortunately, the inherent heterogeneity within tumors raises multiple challenges in deciphering key biomarkers and ...
Cátia F. Monteiro, I. Deus, I. Silva, I. Duarte, C. Custódio, J. Mano   +5 more
semanticscholar   +1 more source

Colorectal Adenocarcinoma Cell Culture in a Microfluidically Controlled Environment with a Static Molecular Gradient of Polyphenol

Molecules, 2021
To study the simultaneous effect of the molecular gradient of polyphenols (curcumin, trans-resveratrol, and wogonin) and biological factors released from tumor cells on apoptosis of adjacent cells, a novel microfluidic system was designed and ...
Roman G. Szafran, Kazimierz Gąsiorowski, Benita Wiatrak   +2 more
doaj   +1 more source