Results 61 to 70 of about 91,694,512 (315)
Frontiers in Cellular Neuroscience, 2020 Glioblastoma (GBM) is the most common and devastating primary brain tumor, leading to a uniform fatality after diagnosis. A major difficulty in eradicating GBM is the presence of microscopic residual infiltrating disease remaining after multimodality ...
Henry Ruiz-Garcia +6 more
doaj +1 more source
Tumor-Vasculature-on-a-Chip for Investigating Nanoparticle Extravasation and Tumor Accumulation
, 2018 Nanoparticle tumor accumulation relies on a key mechanism, the enhanced permeability and retention (EPR) effect, but it remains challenging to decipher the exact impact of the EPR effect.
David A. Weitz (266457) +15 more
core +1 more source
, 2020 The tooth has a unique configuration with respect to biomaterials that are used for its treatment. Cells inside of the dental pulp interface indirectly with biomaterials via a calcified permeable membrane, formed by the dentin matrix and several ...
Bertassoni, Luiz E. +7 more
core +1 more source
Molecules, 2021 To study the simultaneous effect of the molecular gradient of polyphenols (curcumin, trans-resveratrol, and wogonin) and biological factors released from tumor cells on apoptosis of adjacent cells, a novel microfluidic system was designed and ...
Roman G. Szafran +2 more
doaj +1 more source
, 2022 S.3963-3978Organ-on-chip (OoC) systems have become a promising tool for personalized medicine and drug development with advantages over conventional animal models and cell assays.
Rogal, Julia +8 more
core +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Different Microfluidic Environments for In Vitro Testing of Lipid Nanoparticles against Osteosarcoma
Bioengineering, 2021 The use of lipid nanoparticles as biodegradable shells for controlled drug delivery shows promise as a more effective and targeted tumor treatment than traditional treatment methods.
Oihane Mitxelena-Iribarren +4 more
doaj +1 more source
3D Inkjet-Bioprinted Lung-on-a-Chip
, 2023 There is an urgent need for physiologically relevant and customizable biochip models of human lung tissue to provide a niche for lung disease modeling and drug efficacy.
Dayoon Kang +11 more
core +1 more source
Advances in Modeling the Immune Microenvironment of Colorectal Cancer
Frontiers in Immunology, 2021 Colorectal cancer (CRC) is the third most common cancer and second leading cause of cancer-related death in the US. CRC frequently metastasizes to the liver and these patients have a particularly poor prognosis.
Paul Sukwoo Yoon +8 more
doaj +1 more source
A Microfluidic Tumor‐on‐a‐Chip for Assessing Multifunctional Liposomes' Tumor Targeting and Anticancer Efficacy [PDF]
Advanced Healthcare Materials, 2019 AbstractTwo principal methods for cancer drug testing are widely used, namely, in vitro 2D cell monolayers and in vivo animal models. In vitro 2D culture systems are simple and convenient but are unable to capture the complexity of biological processes. Animal models are costly, time‐consuming, and often fail to replicate human activity.
Rui Ran +7 more
openaire +5 more sources