Results 81 to 90 of about 127,911,481 (277)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Lab on a chip for continuous-flow magnetic cell separation [PDF]

, 2015
Separation of cells is a key application area of lab-on-a-chip (LOC) devices. Among the various methods, magnetic separation of cells utilizing microfluidic devices offers the merits of biocompatibility, efficiency, and simplicity.
Nguyen, Nam-Trung, Hejazian, Majid, Weihua Li, Li, Weihua, Nam-Trung Nguyen, Nam-Trung, Nguyen, Majid Hejazian   +6 more
core   +1 more source

Microfluidic-Based 3D Engineered Microvascular Networks and Their Applications in Vascularized Microtumor Models

Micromachines, 2018
The microvasculature plays a critical role in human physiology and is closely associated to various human diseases. By combining advanced microfluidic-based techniques, the engineered 3D microvascular network model provides a precise and reproducible ...
Xiaolin Wang, Qiyue Sun, Jianghua Pei
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

3D printed nervous system on a chip

, 2015
Bioinspired organ-level in vitro platforms are emerging as effective technologies for fundamental research, drug discovery, and personalized healthcare. In particular, models for nervous system research are especially important, due to the complexity of ...
Meng, Fanben, Johnson, Blake N, McAlpine, Michael C, Lancaster, Karen Z, Enquist, Lynn W, Hogue, Ian B, Kong, Yong Lin   +6 more
core   +1 more source

Numerical simulation of titanium alloy dry machining with a strain softening constitutive law [PDF]

, 2010
In this study, the commercial finite element software FORGE2005, able to solve complex thermo-mechanical problems is used to model titanium alloy dry machining.
CALAMAZ, Madalina, Madalina Calamaz, GIROT, Franck, Frank Girot, COUPARD, Dominique, Dominique Coupard   +5 more
core   +1 more source

Emergent trends in organ-on-a-chip applications for investigating metastasis within tumor microenvironment: A comprehensive bibliometric analysis

Heliyon
Background: With the burgeoning advancements in disease modeling, drug development, and precision medicine, organ-on-a-chip has risen to the forefront of biomedical research.
Chunrong He, Fangfang Lu, Yi Liu, Yuanhu Lei, Xiaoxu Wang, Ning Tang   +5 more
doaj   +1 more source

Integrated human organ-on-a-chip model for predictive studies of anti-tumor drug efficacy and cardiac safety

Lab on a Chip, 2020
Traditional drug screening models are often unable to faithfully recapitulate human physiology in health and disease, motivating the development of microfluidic organs-on-a-chip (OOC) platforms that can mimic many aspects of human physiology and in the ...
Alan G Chramiec, Diogo Teles, K. Yeager, Alessandro Marturano-Kruik, Joseph Pak, Timothy Chen, Luke Hao, Miranda C. Wang, Roberta I. Lock, D. Tavakol, M. Lee, Jinho Kim, Kacey Ronaldson-Bouchard, G. Vunjak-Novakovic   +13 more
semanticscholar   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source