Results 71 to 80 of about 138,643 (133)

Engineering Heterogeneous Tumor Models for Biomedical Applications

Advanced Science
Tumor tissue engineering holds great promise for replicating the physiological and behavioral characteristics of tumors in vitro. Advances in this field have led to new opportunities for studying the tumor microenvironment and exploring potential anti ...
Zhuhao Wu, Danqing Huang, Jinglin Wang, Yuanjin Zhao, Weijian Sun, Xian Shen   +5 more
doaj   +1 more source

A Reductionist Metastasis-on-a-Chip Platform for In Vitro Tumor Progression Modeling and Drug Screening

Biotechnology and Bioengineering, 2016
Current animal and 2‐D cell culture models employed in metastasis research and drug discovery remain poor mimics of human cancer physiology. Here we describe a “metastasis‐on‐a‐chip” system allowing real time tracking of fluorescent colon cancer cells ...
A. Skardal, Mahesh Devarasetty, S. Forsythe, A. Atala, S. Soker   +4 more
semanticscholar   +1 more source

Construction of Multicellular Tumor-on-a-Chip Models for Ovarian Cancer Research

Engineering
Ovarian cancer remains a highly lethal gynecologic malignancy. Early diagnosis poses significant challenges, and the five-year survival rate is consistently below 45%. Current standard-of-care combines surgical resection with platinum-based chemotherapy.
Jiexian Ye, Hao Lin, Zilin Zhang, Shihui Xu, Feili Yang, Xuemei Zhuansun, Feng Ji, Yusha Zhang, Yuxin Zhu, Jing Zhang, Zaozao Chen, Zhongze Gu, Yang Shen   +12 more
doaj   +1 more source

How organ-on-a-chip is advancing cancer research and oncology - a cancer hallmarks’ perspective

Frontiers in Lab on a Chip Technologies
Despite significant improvements in methodologies behind the development of new anticancer therapies, the path from early-stage drug development through preclinical and clinical development pipeline is still arduous.
Leela Rani Avula, Piotr Grodzinski
doaj   +1 more source

Tailoring esophageal tumor spheroids on a chip with inverse opal scaffolds for drug screening

Materials Futures
Esophageal cancer (EC) is characterized by high morbidity and mortality, and chemotherapy has become an indispensable means for comprehensive treatment.
Ruolin Shi, Xiangyi Wu, Yuanjin Zhao, Shegan Gao, Gaofeng Liang   +4 more
doaj   +1 more source

Assessing personalized responses to anti-PD-1 treatment using patient-derived lung tumor-on-chip

Cell Reports Medicine
Summary There is a compelling need for approaches to predict the efficacy of immunotherapy drugs. Tumor-on-chip technology exploits microfluidics to generate 3D cell co-cultures embedded in hydrogels that recapitulate simplified tumor ecosystems.
I. Veith, M. Nurmik, A. Mencattini, Isabelle Damei, Christine Lansche, S. Brosseau, Giacomo Gropplero, Stéphanie Corgnac, J. Filippi, Nicolas Poté, Édouard Guenzi, Anaïs Chassac, P. Mordant, J. Tosello, C. Sedlik, Eliane Piaggio, N. Girard, J. Camonis, Hamasseh Shirvani, F. Mami-Chouaib, F. Mechta‐Grigoriou, S. Descroix, Eugenio Martinelli, Gérard Zalcman, M. Parrini   +24 more
semanticscholar   +1 more source

Multimodal Multiorgan‐on‐a‐Chip Platform for Probing Liver‐Tumor Interactions and Advancing Prodrug Screening

Advanced Science
To advance the development of microphysiological systems with enhanced metabolic fidelity, there is a critical need to recapitulate native three‐dimensional multicellular architecture, enabling non‐invasive, multi‐parameter measurements. Here, we present
Dan Wang, Yisong Huang, Weijian Zhao, Tian Chen, Siyu Bai, Denghui Guo, Mengying Wang, Yaoyao Zhao, Liang Zhao, Guangsheng Guo, Xiayan Wang   +10 more
doaj   +1 more source

3D Biomimetic Models to Reconstitute Tumor Microenvironment In Vitro: Spheroids, Organoids, and Tumor-on-a-Chip. [PDF]

Adv Healthc Mater, 2023
Li W, Zhou Z, Zhou X, Khoo BL, Gunawan R, Chin YR, Zhang L, Yi C, Guan X, Yang M.   +9 more
europepmc   +1 more source

Global Literature Analysis of Tumor Organoid and Tumor-on-Chip Research

Cancers
Simple Summary Tumor organoids and tumor-on-chip are three-dimensional tumor cultures that are increasingly used to model cancers in preclinical research.
Jun Shoji, R. Davis, C. Mummery, Stefan Krauss   +3 more
semanticscholar   +1 more source

Biofabrication approaches and regulatory framework of metastatic tumor-on-a-chip models for precision oncology. [PDF]

Med Res Rev, 2022
Nieto D, Jiménez G, Moroni L, López-Ruiz E, Gálvez-Martín P, Marchal JA.   +5 more
europepmc   +1 more source