Results 91 to 100 of about 91,694,512 (315)

3D printed nervous system on a chip

, 2015
Bioinspired organ-level in vitro platforms are emerging as effective technologies for fundamental research, drug discovery, and personalized healthcare. In particular, models for nervous system research are especially important, due to the complexity of ...
Meng, Fanben, Johnson, Blake N, McAlpine, Michael C, Lancaster, Karen Z, Enquist, Lynn W, Hogue, Ian B, Kong, Yong Lin   +6 more
core   +1 more source

Vascularized tumor-on-a-chip to investigate immunosuppression of CAR-T cells

Lab on a Chip
Using a “tumor-on-chip” model, we found that the presence of M2-like macrophages increases PD-L1 and decreases ICAM-1 expression in the endothelial cell leading to abrogation of CAR-T cell effector function (created with BioRender).
Rajul S. Bains, Tara G. Raju, Layla C. Semaan, Anton Block, Yukiko Yamaguchi, Saul J. Priceman, Steven C. George, Venktesh S. Shirure   +7 more
openaire   +3 more sources

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Acoustic formation of multicellular tumor spheroids enabling on-chip functional and structural imaging

, 2018
Understanding the complex 3D tumor microenvironment is important in cancer research. This microenvironment can be modelled in vitro by culturing multicellular tumor spheroids (MCTS).
Olofsson, K., Frisk, T.,, Frisk, T., Önfelt, B., Önfelt, Björn,, Önfelt, B.,, Lundqvist, A., Wiklund, M.,, Kushiro, K.,, Kushiro, K., Olofsson, K.,, Lundqvist, A.,, Carannante, V., Olofsson, Karl,, Takai, M., Wiklund, M., Takai, M.,, Frisk, Thomas,, Ohlin, Mathias, Carannante, V.,, Ohlin, Mathias,, Wiklund, Martin,   +21 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Microfluidic chips for decoding cancer-immune crosstalk in immunotherapy

Frontiers in Immunology
The crosstalk between cancer cells and the immune system within the tumor microenvironment (TME) governs the efficacy of immunotherapeutic interventions.
Xianlei Cai, Xia Xiao, Congcong Zhang, Weiming Yu   +3 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A flexible lab-on-a-chip for the synthesis and magnetic separation of magnetite decorated with gold nanoparticles

, 2015
Magnetite decorated with gold nanoparticles (Fe3O4-AuNPs) is a ferrimagnetic material with unprecedented applications in immunosensors, as a contrast agent for imaging diagnosis, and for the photothermal ablation of tumor cells.
Souza, Joao C. P. de, Cabrera, Flavio C., Crespilho, Frank N., Job, Aldo E. [UNESP], Cabrera, Flavio C. [UNESP], Melo, Antonio F. A. A., Job, Aldo E.   +6 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Performability/energy trade-off in error-control schemes for on-chip networks

, 2010
High reliability against noise, high performance, and low energy consumption are key objectives in the design of on-chip networks. Recently some researchers have considered the impact of various error-control schemes on these objectives and on the trade ...
Ejlali A., Rosinger, Paul, Rosinger P., Al Hashimi B. M., Miremadi S. G., Benini, Luca, Al-Hashimi, Bashir M., Ejlali, Alireza, Miremadi, Seyed Ghassem   +8 more
core   +1 more source