Results 111 to 120 of about 138,643 (133)

Tumor-on-a-chip devices for cancer immunotherapy

Engineering Technologies and Clinical Translation, 2022
This chapter introduces a range of microfluidics-based approaches to the manipulation of immune cells and the recapitulation of the tumor microenvironment, i.e., Tumor-on-a-Chip, for elucidating the mechanism of immune surveillance and for advancing ...
X. Mu, Y. S. Zhang
semanticscholar   +1 more source

Vascularized tumor-on-a-chip to investigate immunosuppression of CAR-T cells.

Lab on a Chip
Chimeric antigen receptor (CAR)-T cell immunotherapy, effective in blood cancers, shows limited success in solid tumors, such as prostate, pancreatic, and brain cancers due, in part, to an immunosuppressive tumor microenvironment (TME). Immunosuppression
Rajul S Bains, Tara G Raju, Layla C. Semaan, Anton V Block, Yukiko Yamaguchi, S. Priceman, Steven C. George, V. Shirure   +7 more
semanticscholar   +1 more source

Vascularized Tumor Spheroid-on-a-Chip Model Verifies Synergistic Vasoprotective and Chemotherapeutic Effects.

ACS Biomaterials Science & Engineering, 2022
Prolyl hydroxylases (PHD) inhibitors have been observed to improve drug distribution in mice tumors via blood vessel normalization, increasing the effectiveness of chemotherapy. These effects are yet to be demonstrated in human cell models.
Zhiwei Hu, Yuanxiong Cao, Edgar A. Galan, Liang Hao, Haoran Zhao, Jiyuan Tang, Gan Sang, H. Wang, Bing Xu, Shaohua Ma   +9 more
semanticscholar   +1 more source

An Overview of Advancements and Technologies in Vascularization Strategies for Tumor‐On‐A‐Chip Models

Advances in Therapy
Vascularized tumor on a chip (VToC) entail emulating intricate microvascular networks like those observed in tumors through microfluidic devices, which are meticulously designed to offer a faithful representation of cancer in vitro, exploration of tumor ...
Pratibha Parihar, Naina Sunildutt, Chethikkattuveli Salih Abdul Rahim, A. Samantasinghar, J. Lim, Kyung-Hyun Choi   +5 more
semanticscholar   +1 more source

Interrogating Matrix Stiffness and Metabolomics in Pancreatic Ductal Carcinoma Using an Openable Microfluidic Tumor-on-a-Chip.

ACS Applied Materials and Interfaces
Pancreatic ductal adenocarcinoma (PDAC) is characterized by a dense fibrotic stroma that contributes to aggressive tumor biology and therapeutic resistance.
Michael D Mohan, Neda Latifi, R. Flick, Craig A. Simmons, Edmond W K Young   +4 more
semanticscholar   +1 more source

Fabrication of a self-assembled and vascularized tumor array via bioprinting on a microfluidic chip.

Lab on a Chip, 2023
A tumor microenvironment (TME) is a complex system that comprises various components, including blood vessels that play a crucial role in supplying nutrients, oxygen, and growth factors, as well as delivering chemotherapy drugs to the tumor mass through ...
G. Lee, Soo Jee Kim, J. Park
semanticscholar   +1 more source

DLM-GelMA/tumor slice sandwich structured tumor on a chip for drug efficacy testing.

Lab on a Chip
The in vitro recapitulation of tumor microenvironment is of great interest to preclinical screening of drugs. Compared with culture of cell lines, tumor organ slices can better preserve the complex tumor architecture and phenotypic activity of native ...
Wenqi Hu, H. Bei, H. Jiang, Di Wu, Xiaorui Yu, Xintong Zhou, Qiuwan Sun, Qinrui Lu, Qijun Du, Liangwen Wang, Zhi Luo, Guohua Wu, Xin Zhao, Shuqi Wang   +13 more
semanticscholar   +1 more source

Tumor spheroid-on-a-chip: a standardized microfluidic culture platform for investigating tumor angiogenesis.

Lab on a Chip, 2019
The field of microfluidics-based three-dimensional (3D) cell culture system is rapidly progressing from academic proof-of-concept studies to valid solutions to real-world problems.
Jihoon Ko, Jungho Ahn, Suryong Kim, Younggyun Lee, Jungseub Lee, Dohyun Park, N. Jeon   +6 more
semanticscholar   +1 more source

Tumor-Vasculature-on-a-Chip for Investigating Nanoparticle Extravasation and Tumor Accumulation.

ACS Nano, 2018
Nanoparticle tumor accumulation relies on a key mechanism, the enhanced permeability and retention (EPR) effect, but it remains challenging to decipher the exact impact of the EPR effect.
Haofei Wang, Rui Ran, Yun Liu, Yue Hui, Bijun Zeng, Dong Chen, D. Weitz, Chun‐Xia Zhao   +7 more
semanticscholar   +1 more source

Rocking- and diffusion-based culture of tumor spheroids-on-a-chip.

Lab on a Chip
Tumor spheroids are now intensively investigated toward preclinical and clinical applications, necessitating the establishment of accessible and cost-effective methods for routine operations.
Duomei Tian, Zheng Mao, Li Wang, Xiaochen Huang, Wei Wang, Haoyue Luo, Juan Peng, Yong Chen   +7 more
semanticscholar   +1 more source