Results 111 to 120 of about 127,911,481 (277)
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
From Separation on a Chip to Laboratory on a Chip
, 2008 Lab on a Chip (called ""Microfluidics"") has established itself as an important technology in the area..
林炳承, 秦建华
core
Controllable Histotomy Based on Hierarchical Magnetic Microneedle Array Robots
EngineeringInvestigation of patient-derived primary tissues is of great importance in the biomedical field, but recent tissue slicing and cultivation techniques still have difficulties in satisfying clinical requirements.
Xiaoxuan Zhang +4 more
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Immuno-oncology on chip: recreating and measuring heterogenous cell battling in tumor ecosystem
, 2019 The immune system is a striking example of an integrated information system, engaged in coordinated host-protective activities. The heterogeneity of immune infiltrate in tumors is now well recognized as an emerging determinant of the efficacy of the ...
Martinelli E +6 more
core
Performability/energy trade-off in error-control schemes for on-chip networks
, 2010 High reliability against noise, high performance, and low energy consumption are key objectives in the design of on-chip networks. Recently some researchers have considered the impact of various error-control schemes on these objectives and on the trade ...
Ejlali A. +8 more
core +1 more source
Engineering Heterogeneous Tumor Models for Biomedical Applications
Advanced ScienceTumor tissue engineering holds great promise for replicating the physiological and behavioral characteristics of tumors in vitro. Advances in this field have led to new opportunities for studying the tumor microenvironment and exploring potential anti ...
Zhuhao Wu +5 more
doaj +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Liquid Biopsy in Colorectal Cancer-Current Status and Potential Clinical Applications
Micromachines, 2018 Colorectal cancer is one of the most frequent solid malignancies worldwide. The treatment is either surgical or multimodal and depends on the stage of the disease at diagnosis. Accurate disease assessment is thus of great importance for choosing the most
Gregor Norcic
doaj +1 more source
Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma
Molecular Oncology, EarlyView.Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara +10 more
wiley +1 more source