Results 121 to 130 of about 127,911,481 (277)

Integrated Parylene LC-ESI on a Chip [PDF]

open access: yes, 2005
In this thesis, several microfluidic devices will be introduced to demonstrate the integration capability of a multilayer parylene surface micromachining technology.
Xie, Jun
core   +1 more source

Construction of Multicellular Tumor-on-a-Chip Models for Ovarian Cancer Research

open access: yesEngineering
Ovarian cancer remains a highly lethal gynecologic malignancy. Early diagnosis poses significant challenges, and the five-year survival rate is consistently below 45%. Current standard-of-care combines surgical resection with platinum-based chemotherapy.
Jiexian Ye   +12 more
doaj   +1 more source

Embolization-on-a-chip: novel vascularized liver tumor model for evaluation of cellular and cytokine response to embolic agents

open access: yesbioRxiv
Blood vessel embolization is a well-established treatment modality for liver cancer. Novel shear-thinning hydrogels (STH) have been developed to address the need for safer and more effective local delivery of embolic agents and therapeutics.
Huu Tuan Nguyen   +17 more
semanticscholar   +1 more source

A 3D Human Renal Cell Carcinoma-on-a-Chip for the Study of Tumor Angiogenesis1

open access: yesNeoplasia, 2018
Tractable human tissue-engineered 3D models of cancer that enable fine control of tumor growth, metabolism, and reciprocal interactions between different cell types in the tumor microenvironment promise to accelerate cancer research and pharmacologic ...
Chris P. Miller   +4 more
semanticscholar   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

open access: yesFEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill   +6 more
wiley   +1 more source

Human brain organoid-on-a-chip to model prenatal nicotine exposure

open access: yes, 2018
Nicotine has been recognized to trigger various neuronal disabilities in the fetal brain and long-lasting behavioral deficits in offspring. However, further understanding of fetal brain development under nicotine exposure is challenging due to the ...
Qin, Jianhua   +7 more
core   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

open access: yesFEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss   +7 more
wiley   +1 more source

PDMS lab-on-a-chip fabrication using 3D printed templates

open access: yes, 2014
G. Comina's research stay at Linkoping University has been financed by the Peruvian National Council for Science and Technology (CONCYTEC). This research has been supported by grants from Linkoping Centre for Life Science Technologies (LIST), Sweden, and
Comina, G   +5 more
core   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

open access: yesFEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito   +7 more
wiley   +1 more source

Tumor Microenvironment on a Chip: The Progress and Future Perspective

open access: yesBioengineering, 2017
Tumors develop in intricate microenvironments required for their sustained growth, invasion, and metastasis. The tumor microenvironment plays a critical role in the malignant or drug resistant nature of tumors, becoming a promising therapeutic target ...
Jungho Ahn   +3 more
doaj   +1 more source

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